Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 552 aa | 22.8 % |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 519 aa | 20.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0659 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0659 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0659 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0659 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0659 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0659 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0659 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0659 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0659 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0659 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0659 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0659 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0659 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0659 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0659 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0659 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0659 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0659 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0659 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0659 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0659 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0659 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0659 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.18 uM | Inhibition of human FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis | ChEMBL. | 23528296 |
IC50 (binding) | = 5.4 uM | Inhibition of mouse FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis | ChEMBL. | 23528296 |
Stabilty (ADMET) | = 53 % | Metabolic stability in mouse liver microsomes assessed as compound remaining after 0.5 hr | ChEMBL. | 23528296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.