Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Mus musculus | solute carrier family 27 (fatty acid transporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 519 aa | 20.4 % |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | solute carrier family 27 (fatty acid transporter), member 1 | 646 aa | 552 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0231 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0221 | 0.954 | 1 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Schistosoma mansoni | FFA transport protein | 0.0224 | 0.9672 | 1 |
Leishmania major | fatty acid transporter protein-like protein | 0.0221 | 0.954 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0221 | 0.954 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0224 | 0.9672 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Toxoplasma gondii | propionate-CoA ligase | 0.001 | 0 | 0.5 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0231 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0224 | 0.9672 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.001 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.001 | 0 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.077 uM | Inhibition of human FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis | ChEMBL. | 23528296 |
IC50 (binding) | = 4 uM | Inhibition of mouse FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis | ChEMBL. | 23528296 |
Stabilty (ADMET) | = 42 % | Metabolic stability in mouse liver microsomes assessed as compound remaining after 0.5 hr | ChEMBL. | 23528296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.