Detailed information for compound 1767085

Basic information

Technical information
  • TDR Targets ID: 1767085
  • Name: N-(4,5-dimethyl-1,3-thiazol-2-yl)-2-[4-(4-flu orophenyl)piperazin-1-yl]acetamide
  • MW: 348.438 | Formula: C17H21FN4OS
  • H donors: 1 H acceptors: 2 LogP: 3.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1sc(c(n1)C)C)CN1CCN(CC1)c1ccc(cc1)F
  • InChi: 1S/C17H21FN4OS/c1-12-13(2)24-17(19-12)20-16(23)11-21-7-9-22(10-8-21)15-5-3-14(18)4-6-15/h3-6H,7-11H2,1-2H3,(H,19,20,23)
  • InChiKey: BZPATJSZDVWBOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,5-dimethylthiazol-2-yl)-2-[4-(4-fluorophenyl)piperazin-1-yl]acetamide
  • N-(4,5-dimethyl-2-thiazolyl)-2-[4-(4-fluorophenyl)-1-piperazinyl]acetamide
  • N-(4,5-dimethyl-1,3-thiazol-2-yl)-2-[4-(4-fluorophenyl)piperazin-1-yl]ethanamide
  • T5775609

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus solute carrier family 27 (fatty acid transporter), member 1 Starlite/ChEMBL References
Homo sapiens solute carrier family 27 (fatty acid transporter), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Get druggable targets OG5_127399 All targets in OG5_127399
Trypanosoma cruzi fatty acid transporter protein-like, putative Get druggable targets OG5_127399 All targets in OG5_127399
Leishmania donovani fatty acid transporter protein-like protein Get druggable targets OG5_127399 All targets in OG5_127399
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_127399 All targets in OG5_127399
Mycobacterium leprae possible long-chain acyl-CoA synthase Get druggable targets OG5_127399 All targets in OG5_127399
Schistosoma japonicum Long-chain fatty acid transport protein 4, putative Get druggable targets OG5_127399 All targets in OG5_127399
Trypanosoma cruzi fatty acid transporter protein-like, putative Get druggable targets OG5_127399 All targets in OG5_127399
Schistosoma mansoni FFA transport protein Get druggable targets OG5_127399 All targets in OG5_127399
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Get druggable targets OG5_127399 All targets in OG5_127399
Loa Loa (eye worm) AMP-binding enzyme family protein Get druggable targets OG5_127399 All targets in OG5_127399
Leishmania mexicana fatty acid transporter protein-like protein Get druggable targets OG5_127399 All targets in OG5_127399
Leishmania braziliensis fatty acid transporter protein-like protein Get druggable targets OG5_127399 All targets in OG5_127399
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_127399 All targets in OG5_127399
Echinococcus multilocularis long chain fatty acid transport protein 4 Get druggable targets OG5_127399 All targets in OG5_127399
Leishmania major fatty acid transporter protein-like protein Get druggable targets OG5_127399 All targets in OG5_127399
Mycobacterium ulcerans long-chain-acyl-CoA synthetase Get druggable targets OG5_127399 All targets in OG5_127399
Leishmania infantum fatty acid transporter protein-like protein Get druggable targets OG5_127399 All targets in OG5_127399
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Get druggable targets OG5_127399 All targets in OG5_127399
Echinococcus granulosus long chain fatty acid transport protein 4 Get druggable targets OG5_127399 All targets in OG5_127399
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 solute carrier family 27 (fatty acid transporter), member 1 646 aa 519 aa 20.4 %
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) solute carrier family 27 (fatty acid transporter), member 1 646 aa 552 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi Tachykinin-like peptides receptor 99D 0.0066 0.2484 0.2381
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.2484 0.2463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis g protein coupled receptor 0.0066 0.2484 0.2463
Echinococcus granulosus hypothetical protein 0.0066 0.2484 0.2463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Schistosoma mansoni neuropeptide receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.2484 0.2381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis fmrfamide receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.2484 0.2463
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0066 0.2484 0.2463
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.3152 0.326
Echinococcus granulosus 7TM GPCR rhodopsin 0.0066 0.2484 0.2463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.2484 0.2463
Echinococcus multilocularis somatostatin receptor 0.0066 0.2484 0.2463
Onchocerca volvulus Neuropeptide F receptor homolog 0.0066 0.2484 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.2842 0.2744
Echinococcus multilocularis G protein coupled receptor 139 0.0066 0.2484 0.2463
Schistosoma mansoni neuropeptide f receptor 76f 0.0066 0.2484 0.2569
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.2484 0.2569
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi G protein-coupled receptor F59B2.13 0.0066 0.2484 0.2381
Brugia malayi follicle stimulating hormone receptor 0.0066 0.2484 0.2381
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.2484 0.2463
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.2484 0.2569
Schistosoma mansoni biogenic amine receptor 0.0066 0.2484 0.2569
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0136 0.014
Echinococcus granulosus g-protein coupled receptor 0.0066 0.2484 0.2463
Brugia malayi G protein-coupled receptor 0.0066 0.2484 0.2381
Schistosoma mansoni amine GPCR 0.0066 0.2484 0.2569
Brugia malayi G-protein coupled receptor 0.0066 0.2484 0.2381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0066 0.2484 0.2381
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0446 0.0325
Loa Loa (eye worm) hypothetical protein 0.0021 0.0446 0.0314
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni hypothetical protein 0.0066 0.2484 0.2569
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Onchocerca volvulus 0.0066 0.2484 0.5
Brugia malayi sulfakinin receptor protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni FFA transport protein 0.0224 0.967 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.2484 0.2569
Echinococcus granulosus alpha 1A adrenergic receptor 0.0066 0.2484 0.2463
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0066 0.2484 0.2463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0066 0.2484 0.2381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis sex peptide receptor 0.0066 0.2484 0.2463
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0066 0.2484 0.2381
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi Serotonin receptor 0.0066 0.2484 0.2381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi G-protein coupled receptor 0.0066 0.2484 0.2381
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.262 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0066 0.2484 0.2463
Echinococcus multilocularis fmrfamide receptor 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis neuropeptide receptor 0.0066 0.2484 0.2463
Brugia malayi Dopamine receptor protein 1 0.0066 0.2484 0.2381
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.2484 0.2463
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0136 0.014
Echinococcus granulosus biogenic amine 5HT receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi GnHR receptor homolog 0.0066 0.2484 0.2381
Schistosoma mansoni amine GPCR 0.0066 0.2484 0.2569
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni opsin-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni neuropeptide receptor 0.0066 0.2484 0.2569
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Schistosoma mansoni amine GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis orexin receptor type 2 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus multilocularis serotonin receptor 0.0066 0.2484 0.2463
Schistosoma mansoni growth hormone secretagogue receptor 0.0066 0.2484 0.2569
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) melatonin receptor type 1A 0.0066 0.2484 0.2381
Brugia malayi putative neuropeptide receptor 0.0066 0.2484 0.2381
Brugia malayi RE15519p 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis g-protein coupled receptor 0.0066 0.2484 0.2463
Echinococcus granulosus neuropeptides capa receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0066 0.2484 0.2463
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni histamine h1 receptor 0.0066 0.2484 0.2569
Onchocerca volvulus 0.0066 0.2484 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0066 0.2484 0.2381
Echinococcus granulosus long chain fatty acid transport protein 4 0.0224 0.967 1
Echinococcus multilocularis neuropeptide s receptor 0.0066 0.2484 0.2463
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0066 0.2484 0.2569
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0224 0.967 1
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0446 0.0461
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0066 0.2484 0.2381
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0066 0.2484 0.2463
Echinococcus granulosus neuropeptide s receptor 0.0066 0.2484 0.2463
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0066 0.2484 0.2463
Schistosoma mansoni biogenic amine (5HT) receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.2842 0.2744
Onchocerca volvulus 0.0066 0.2484 0.5
Brugia malayi neuropeptide F receptor 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni hypothetical protein 0.0066 0.2484 0.2569
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0066 0.2484 0.2569
Echinococcus granulosus g protein coupled receptor 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0066 0.2484 0.2463
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0066 0.2484 0.2569
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0221 0.9537 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0136 0.014
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis dro:myosuppressin receptor 0.0066 0.2484 0.2463
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.2842 0.2839
Schistosoma mansoni opsin-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0066 0.2484 0.2569
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0136 0.014
Echinococcus multilocularis neuropeptide Y receptor 0.0066 0.2484 0.2463
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0446 0.0461
Echinococcus multilocularis G-protein coupled receptor, putative 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus granulosus neuropeptide receptor 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0066 0.2484 0.2569
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0136 0.014
Echinococcus multilocularis neuropeptide receptor A26 0.0066 0.2484 0.2463
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.3152 0.326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Schistosoma mansoni neuropeptide receptor 0.0066 0.2484 0.2569
Schistosoma mansoni neuropeptide receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0066 0.2484 0.2381
Schistosoma mansoni myosin xvIII 0.0066 0.2484 0.2569
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0066 0.2484 0.2463
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0224 0.967 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni biogenic amine receptor 0.0066 0.2484 0.2569
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.2484 0.2463
Onchocerca volvulus 0.0066 0.2484 0.5
Brugia malayi neuropeptide F receptor 0.0066 0.2484 0.2381
Echinococcus granulosus g protein coupled receptor 0.0066 0.2484 0.2463
Brugia malayi Dopamine receptor protein 2 0.0066 0.2484 0.2381
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.262 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0066 0.2484 0.2463
Schistosoma mansoni opsin-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0066 0.2484 0.2569
Echinococcus granulosus allatostatin A receptor 0.0066 0.2484 0.2463
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus neuropeptide receptor 0.0066 0.2484 0.2463
Schistosoma mansoni alpha-1 adrenergic receptor 0.0066 0.2484 0.2569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0221 0.9537 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.2484 0.2463
Schistosoma mansoni amine GPCR 0.0066 0.2484 0.2569
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0446 0.0325
Onchocerca volvulus 0.0066 0.2484 0.5
Leishmania major fatty acid transporter protein-like protein 0.0221 0.9537 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0066 0.2484 0.2463
Schistosoma mansoni biogenic amine receptor 0.0066 0.2484 0.2569
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0224 0.967 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0066 0.2484 0.2463
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0066 0.2484 0.2569
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0066 0.2484 0.2463
Echinococcus granulosus neuropeptide Y receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus orexin receptor type 2 0.0066 0.2484 0.2463
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0066 0.2484 0.2463
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0066 0.2484 0.2463
Echinococcus granulosus sex peptide receptor 0.0066 0.2484 0.2463
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0136 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Echinococcus multilocularis g protein coupled receptor 0.0066 0.2484 0.2463
Echinococcus granulosus serotonin receptor 0.0066 0.2484 0.2463
Brugia malayi Melatonin receptor type 1A 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis serotonin receptor 0.0066 0.2484 0.2463
Schistosoma mansoni adenoreceptor 0.0066 0.2484 0.2569
Brugia malayi AKH receptor 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0066 0.2484 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.2842 0.2839
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0066 0.2484 0.2569
Brugia malayi Serotonin receptor 0.0066 0.2484 0.2381
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0066 0.2484 0.2463
Echinococcus granulosus fmrfamide receptor 0.0066 0.2484 0.2463
Echinococcus granulosus g protein coupled receptor 0.0066 0.2484 0.2463
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0066 0.2484 0.2463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0066 0.2484 0.2381
Schistosoma mansoni amine GPCR 0.0066 0.2484 0.2569
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.2484 0.2381
Onchocerca volvulus 0.0066 0.2484 0.5
Onchocerca volvulus 0.0066 0.2484 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0446 0.0325
Brugia malayi larval opioid receptor 0.0066 0.2484 0.2381
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.2484 0.2463
Echinococcus multilocularis allatostatin A receptor 0.0066 0.2484 0.2463
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0066 0.2484 0.2463
Echinococcus granulosus peptide allatostatin:somatostatin 0.0066 0.2484 0.2463
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0066 0.2484 0.2381
Onchocerca volvulus 0.0066 0.2484 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Echinococcus granulosus tm gpcr rhodopsin 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0064 0.2397 0.2292
Brugia malayi hypothetical protein 0.0066 0.2484 0.2381
Loa Loa (eye worm) G-protein coupled receptor 0.0066 0.2484 0.2381
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Schistosoma mansoni hypothetical protein 0.0066 0.2484 0.2569
Brugia malayi Dopamine receptor 0.0066 0.2484 0.2381
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus granulosus rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Echinococcus granulosus G protein coupled receptor 139 0.0066 0.2484 0.2463
Echinococcus multilocularis neuropeptide receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Brugia malayi ORL1-like opioid receptor 0.0066 0.2484 0.2381
Echinococcus multilocularis g protein coupled receptor 0.0066 0.2484 0.2463
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0066 0.2484 0.2463
Loa Loa (eye worm) neuropeptide F receptor 0.0066 0.2484 0.2381
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0066 0.2484 0.2569
Schistosoma mansoni hypothetical protein 0.0066 0.2484 0.2569
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0446 0.0325
Echinococcus granulosus dro:myosuppressin receptor 0.0066 0.2484 0.2463
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0446 0.0314
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis neuropeptides capa receptor 0.0066 0.2484 0.2463
Echinococcus granulosus neuropeptide FF receptor 2 0.0066 0.2484 0.2463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0231 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.2484 0.2381
Echinococcus multilocularis rhodopsin orphan GPCR 0.0066 0.2484 0.2463
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0231 1 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0066 0.2484 0.2463
Brugia malayi putative neuropeptide receptor NPR1 0.0066 0.2484 0.2381
Schistosoma mansoni neuropeptide F-like receptor 0.0066 0.2484 0.2569
Echinococcus granulosus somatostatin receptor 0.0066 0.2484 0.2463

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.43 uM Inhibition of human FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis ChEMBL. 23528296
IC50 (binding) = 1.7 uM Inhibition of mouse FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis ChEMBL. 23528296
Stabilty (ADMET) = 56 % Metabolic stability in mouse liver microsomes assessed as compound remaining after 0.5 hr ChEMBL. 23528296

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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