TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.415 | Formula: C20H22N4O
H donors: 0 H acceptors: 2 LogP: 3.84 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c(C)nc2n1cccc2)CN1CCN(CC1)c1ccccc1
InChi: 1S/C20H22N4O/c1-16-20(24-10-6-5-9-19(24)21-16)18(25)15-22-11-13-23(14-12-22)17-7-3-2-4-8-17/h2-10H,11-15H2,1H3
InChiKey: XYLQRPYZNRKMNE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 27 (fatty acid transporter), member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania infantum	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Echinococcus granulosus	long chain fatty acid transport protein 4	Get druggable targets OG5_127399	All targets in OG5_127399
Echinococcus multilocularis	long chain fatty acid transport protein 4	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania major	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania braziliensis	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania mexicana	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma japonicum	ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Loa Loa (eye worm)	AMP-binding enzyme family protein	Get druggable targets OG5_127399	All targets in OG5_127399
Trypanosoma cruzi	fatty acid transporter protein-like, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma mansoni	FFA transport protein	Get druggable targets OG5_127399	All targets in OG5_127399
Brugia malayi	AMP-binding enzyme family protein	Get druggable targets OG5_127399	All targets in OG5_127399
Mycobacterium leprae	possible long-chain acyl-CoA synthase	Get druggable targets OG5_127399	All targets in OG5_127399
Schistosoma japonicum	Long-chain fatty acid transport protein 4, putative	Get druggable targets OG5_127399	All targets in OG5_127399
Candida albicans	similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase	Get druggable targets OG5_127399	All targets in OG5_127399
Leishmania donovani	fatty acid transporter protein-like protein	Get druggable targets OG5_127399	All targets in OG5_127399
Trypanosoma cruzi	fatty acid transporter protein-like, putative	Get druggable targets OG5_127399	All targets in OG5_127399

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	solute carrier family 27 (fatty acid transporter), member 1	646 aa	552 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide receptor A26	0.0047	0.4336	0.4723
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.4336	0.4723
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0047	0.4336	1
Echinococcus granulosus	neuropeptide receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.4336	0.4723
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.4336	0.4723
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0047	0.4336	0.4336
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.4336	0.4723
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0008	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0047	0.4336	0.4336
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.4336	0.4336
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0047	0.4336	0.4336
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Onchocerca volvulus		0.0047	0.4336	1
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus granulosus	serotonin receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0	0.5
Onchocerca volvulus		0.0047	0.4336	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0047	0.4336	0.4336
Schistosoma mansoni	hypothetical protein	0.0047	0.4336	0.4723
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus granulosus	orexin receptor type 2	0.0047	0.4336	0.4723
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0047	0.4336	0.4723
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0008	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	larval opioid receptor	0.0047	0.4336	0.4336
Schistosoma mansoni	histamine h1 receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	G protein coupled receptor 139	0.0047	0.4336	0.4723
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0047	0.4336	0.4723
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0047	0.4336	0.4336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0097	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.4336	0.4723
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0097	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.4336	0.4723
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0047	0.4336	0.4336
Brugia malayi	AKH receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	neuropeptide s receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Schistosoma mansoni	neuropeptide receptor	0.0047	0.4336	0.4723
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0008	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine receptor	0.0047	0.4336	0.4723
Brugia malayi	GnHR receptor homolog	0.0047	0.4336	0.4336
Schistosoma mansoni	opsin-like receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	growth hormone secretagogue receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	g protein coupled receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	myosin xvIII	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	orexin receptor type 2	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.4336	0.4723
Brugia malayi	neuropeptide F receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.4336	0.4723
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0047	0.4336	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0047	0.4336	0.4723
Brugia malayi	putative neuropeptide receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	dro:myosuppressin receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	neuropeptide Y receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.4336	0.4723
Schistosoma mansoni	adenoreceptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	tm gpcr rhodopsin	0.0047	0.4336	0.4723
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.4336	0.4723
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Schistosoma mansoni	hypothetical protein	0.0047	0.4336	0.4723
Echinococcus granulosus	dro:myosuppressin receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	amine GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0	0.5
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0088	0.9048	1
Schistosoma mansoni	amine GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Echinococcus granulosus	somatostatin receptor	0.0047	0.4336	0.4723
Brugia malayi	RE15519p	0.0047	0.4336	0.4336
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0089	0.918	1
Echinococcus multilocularis	serotonin receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	neuropeptide s receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	amine GPCR	0.0047	0.4336	0.4723
Brugia malayi	G protein-coupled receptor F59B2.13	0.0047	0.4336	0.4336
Schistosoma mansoni	hypothetical protein	0.0047	0.4336	0.4723
Leishmania major	fatty acid transporter protein-like protein	0.0088	0.9048	1
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	neuropeptides capa receptor	0.0047	0.4336	0.4723
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0088	0.9048	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0047	0.4336	0.4723
Schistosoma mansoni	opsin-like receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	biogenic amine 5HT receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	neuropeptide receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	sex peptide receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	neuropeptide FF receptor 2	0.0047	0.4336	0.4723
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	neuropeptide receptor A26	0.0047	0.4336	0.4723
Echinococcus multilocularis	neuropeptide receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0089	0.918	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus granulosus	fmrfamide receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	G-protein coupled receptor	0.0047	0.4336	0.4336
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0047	0.4336	0.4723
Brugia malayi	sulfakinin receptor protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	serotonin receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0047	0.4336	0.4723
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Schistosoma mansoni	neuropeptide receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	Dopamine receptor	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	Dopamine receptor protein 1	0.0047	0.4336	0.4336
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	7TM GPCR rhodopsin	0.0047	0.4336	0.4723
Echinococcus multilocularis	allatostatin A receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	melatonin receptor type 1A	0.0047	0.4336	0.4336
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	allatostatin A receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	opsin-like receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	G protein-coupled receptor	0.0047	0.4336	0.4336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Echinococcus granulosus	hypothetical protein	0.0047	0.4336	0.4723
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0047	0.4336	0.4723
Loa Loa (eye worm)	neuropeptide F receptor	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	neuropeptides capa receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	g protein coupled receptor	0.0047	0.4336	0.4723
Brugia malayi	ORL1-like opioid receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Entamoeba histolytica	acyl-coA synthetase, putative	0.0008	0	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0047	0.4336	0.4723
Schistosoma mansoni	FFA transport protein	0.0089	0.918	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0047	0.4336	0.4723
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0089	0.918	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0047	0.4336	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Onchocerca volvulus		0.0047	0.4336	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0008	0	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0047	0.4336	0.4336
Brugia malayi	G-protein coupled receptor	0.0047	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	neuropeptide f receptor 76f	0.0047	0.4336	0.4723
Schistosoma mansoni	neuropeptide receptor	0.0047	0.4336	0.4723
Schistosoma mansoni	neuropeptide F-like receptor	0.0047	0.4336	0.4723
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0008	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	neuropeptide Y receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Brugia malayi	G-protein coupled receptor	0.0047	0.4336	0.4336
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	follicle stimulating hormone receptor	0.0047	0.4336	0.4336
Schistosoma mansoni	amine GPCR	0.0047	0.4336	0.4723
Brugia malayi	putative neuropeptide receptor NPR1	0.0047	0.4336	0.4336
Brugia malayi	Melatonin receptor type 1A	0.0047	0.4336	0.4336
Schistosoma mansoni	biogenic amine receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	neuropeptide receptor	0.0047	0.4336	0.4723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0047	0.4336	0.4723
Echinococcus multilocularis	fmrfamide receptor	0.0047	0.4336	0.4723
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Loa Loa (eye worm)	TYRA-2 protein	0.0047	0.4336	0.4336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Brugia malayi	Serotonin receptor	0.0047	0.4336	0.4336
Echinococcus granulosus	g-protein coupled receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	hypothetical protein	0.0047	0.4336	0.4723
Echinococcus multilocularis	g protein coupled receptor	0.0047	0.4336	0.4723
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0008	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0047	0.4336	0.4723
Echinococcus granulosus	G protein coupled receptor 139	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	sex peptide receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus granulosus	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Brugia malayi	Serotonin receptor	0.0047	0.4336	0.4336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0047	0.4336	0.4723
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0047	0.4336	0.4723
Onchocerca volvulus		0.0047	0.4336	1
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0089	0.918	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0008	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0047	0.4336	0.4723
Brugia malayi	Dopamine receptor protein 2	0.0047	0.4336	0.4336
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0008	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Echinococcus multilocularis	somatostatin receptor	0.0047	0.4336	0.4723
Brugia malayi	neuropeptide F receptor	0.0047	0.4336	0.4336
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0047	0.4336	0.4723
Loa Loa (eye worm)	hypothetical protein	0.0047	0.4336	0.4336
Brugia malayi	hypothetical protein	0.0047	0.4336	0.4336
Schistosoma mansoni	amine GPCR	0.0047	0.4336	0.4723
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0047	0.4336	0.4336
Echinococcus granulosus	g protein coupled receptor	0.0047	0.4336	0.4723
Toxoplasma gondii	propionate-CoA ligase	0.0008	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of mouse FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis	ChEMBL.	23528296
IC50 (binding)	= 3 uM	Inhibition of human FLAG-tagged FATP1-mediated [1-14C] oleic acid conversion to [1-14C] oleoyl-CoA after 20 mins by scintillation counting analysis	ChEMBL.	23528296

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2377768

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1767086