Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nmda type glutamate receptor | 0.0354 | 0.6341 | 0.563 |
Echinococcus multilocularis | serotonin transporter | 0.0197 | 0.1627 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1627 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0354 | 0.6341 | 0.6341 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0333 | 0.5726 | 0.4896 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0197 | 0.1627 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0197 | 0.1627 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0197 | 0.1627 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0333 | 0.5726 | 0.5726 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0197 | 0.1627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1627 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1627 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0476 | 1 | 1 |
Onchocerca volvulus | 0.0197 | 0.1627 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0394 | 0.754 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0197 | 0.1627 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.