Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0583 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0583 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.028 | 0.028 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.028 | 0.028 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.028 | 0.028 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0583 | 1 | 0.5 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0583 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0583 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.028 | 0.028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 60 % | Antifungal activity against Candida albicans ATCC 2091 after 48 hrs by two-fold serial dilution method relative to clotrimazole | ChEMBL. | 23811090 |
GI (functional) | = 104.63 % | Cytotoxicity against human SNB75 cells assessed as growth inhibition at 10 uM | ChEMBL. | 23811090 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.