Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidine phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Echinococcus granulosus | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Mycobacterium ulcerans | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Echinococcus multilocularis | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0216 | 0.2785 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0165 | 0.2119 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.0765 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0101 | 0.1279 | 0.6037 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0011 | 0.0099 | 0.0099 |
Schistosoma mansoni | cell adhesion molecule | 0.0011 | 0.0099 | 0.0466 |
Echinococcus multilocularis | roundabout 2 | 0.0014 | 0.0137 | 0.0137 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0143 | 0.0143 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0101 | 0.1279 | 0.5843 |
Schistosoma mansoni | tyrosine kinase | 0.0098 | 0.1241 | 0.5855 |
Echinococcus granulosus | Immunoglobulin | 0.0011 | 0.0099 | 0.0099 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0137 | 0.0647 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0013 | 0.0112 | 0.053 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0098 | 0.1241 | 0.1241 |
Brugia malayi | Protein kinase domain containing protein | 0.0165 | 0.2119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0011 | 0.0099 | 0.0099 |
Echinococcus granulosus | roundabout 2 | 0.0014 | 0.0137 | 0.0137 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0137 | 0.0137 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0013 | 0.0112 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.0765 | 1 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0011 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Echinococcus multilocularis | thymidine phosphorylase | 0.0765 | 1 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0099 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0137 | 0.0647 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0137 | 0.0137 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0098 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0099 | 0.0099 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0098 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0165 | 0.2119 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0099 | 0.0099 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0099 | 0.0466 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0137 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0099 | 0.0466 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0098 | 0.1241 | 0.1241 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0099 | 0.0466 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.8 uM | Inhibition of human recombinant thymidine phosphorylase expressed in Escherichia coli using thymidine as substrate after 4 to 20 mins by spectrophotometry | ChEMBL. | 23871912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.