Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.8603 | 0.8603 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0085 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0377 | 0.8603 | 0.5 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.0425 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.3166 | 0.3166 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.0425 | 1 | 0.5 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.0425 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0377 | 0.8603 | 0.8603 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0377 | 0.8603 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0377 | 0.8603 | 1 |
Loa Loa (eye worm) | Carm1-pending protein | 0.0425 | 1 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0425 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0085 | 0 | 0.5 |
Onchocerca volvulus | 0.037 | 0.8402 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microdilution plate assay | ChEMBL. | 23886691 | |
MIC (functional) | = 0.4 uM | Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 by microplate alamar blue assay | ChEMBL. | 23886691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.