Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.9959 | 0.9959 | |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0067 | 0.3973 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0067 | 0.3973 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0067 | 0.3973 | 0.3973 |
Brugia malayi | Casein kinase II, alpha chain | 0.0067 | 0.3973 | 0.3973 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0067 | 0.3973 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0067 | 0.3973 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0067 | 0.3973 | 0.3973 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Schistosoma mansoni | protein kinase | 0.0067 | 0.3973 | 0.3973 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0136 | 0.9959 | 0.9959 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0022 | 0 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0067 | 0.3973 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0067 | 0.3973 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0067 | 0.3973 | 0.3973 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0067 | 0.3973 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.3973 | 1 |
Plasmodium vivax | unspecified product | 0.0067 | 0.3973 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0067 | 0.3973 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0067 | 0.3973 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4240 nM | Fluorometric Assay | BINDINGDB. | No reference |
IC50 (binding) | = 4.24 uM | Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase | ChEMBL. | 23886302 |
Ki (binding) | = 790 nM | Fluorometric Assay | BINDINGDB. | No reference |
Ki (binding) | = 0.78 uM | Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase | ChEMBL. | 23886302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.