TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.358 | Formula: C16H12N4OS
H donors: 1 H acceptors: 3 LogP: 3.02 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: c1ccc(cc1)SCc1nnc(o1)c1ccc2c(c1)nc[nH]2
InChi: 1S/C16H12N4OS/c1-2-4-12(5-3-1)22-9-15-19-20-16(21-15)11-6-7-13-14(8-11)18-10-17-13/h1-8,10H,9H2,(H,17,18)
InChiKey: PNGMEQKENMASHD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminyl-peptide cyclotransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	glutaminyl cyclase (M28 family)	Get druggable targets OG5_129821	All targets in OG5_129821
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	Get druggable targets OG5_129821	All targets in OG5_129821
Brugia malayi	Peptidase family M28 containing protein	Get druggable targets OG5_129821	All targets in OG5_129821
Schistosoma japonicum	ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative	Get druggable targets OG5_129821	All targets in OG5_129821
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129821	All targets in OG5_129821
Onchocerca volvulus	Glutaminyl cyclase homolog	Get druggable targets OG5_129821	All targets in OG5_129821
Echinococcus granulosus	glutaminyl peptide cyclotransferase	Get druggable targets OG5_129821	All targets in OG5_129821

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	glutaminyl-peptide cyclotransferase	361 aa	292 aa	21.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0802	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Leishmania major	protein kinase, putative	0.0326	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0476	0.3154	0.3154
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Echinococcus granulosus	c src tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0802	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0802	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.3154	0.3154
Leishmania major	hypothetical protein, conserved	0.0326	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.3154	0.3154
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0802	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0476	0.3154	0.3154
Echinococcus granulosus	SH2 motif	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	hypothetical protein	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein kinase shark	0.0802	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0476	0.3154	0.3154
Leishmania major	protein kinase, putative	0.0326	0	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0476	0.3154	0.3154
Schistosoma mansoni	shc transforming protein	0.0476	0.3154	0.3154
Schistosoma mansoni	tensin-related	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0802	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0802	1	1
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Trypanosoma cruzi	protein kinase, putative	0.0326	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0476	0.3154	0.3154
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0326	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0326	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	Tyrosine-protein kinase abl-1	0.0802	1	1
Schistosoma mansoni	tensin-related	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Plasmodium falciparum	tyrosine kinase-like protein	0.0326	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.3154	0.3154
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0326	0	0.5
Onchocerca volvulus		0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase shark	0.0802	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0476	0.3154	0.3154
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0326	0	0.5
Plasmodium vivax	protein kinase, putative	0.0326	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0802	1	1
Giardia lamblia	Kinase, NEK	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0802	1	1
Echinococcus granulosus	tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0326	0	0.5
Brugia malayi	SH2 domain containing protein	0.0802	1	1
Schistosoma mansoni	tensin	0.0476	0.3154	0.3154
Schistosoma mansoni	SH2A	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0476	0.3154	0.3154
Toxoplasma gondii	protein kinase domain-containing protein	0.0326	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0802	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0476	0.3154	0.3154
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0476	0.3154	0.3154
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Schistosoma mansoni	signal transduction protein lnk-related	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0476	0.3154	0.3154
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0802	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0802	1	1
Echinococcus multilocularis	NCK adaptor protein	0.0476	0.3154	0.3154
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Echinococcus multilocularis	tyrosine kinase	0.0802	1	1
Onchocerca volvulus		0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0802	1	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0326	0	0.5
Onchocerca volvulus		0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	SH2 motif	0.0476	0.3154	0.3154
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0326	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0326	0	0.5
Echinococcus multilocularis		0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0802	1	1
Echinococcus multilocularis	SH2 motif	0.0476	0.3154	0.3154
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0476	0.3154	0.3154
Trichomonas vaginalis	TK family protein kinase	0.0326	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0802	1	1
Brugia malayi	Protein kinase domain containing protein	0.0802	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0326	0	0.5
Echinococcus multilocularis	tensin	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0476	0.3154	0.3154
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0802	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0476	0.3154	0.3154
Loa Loa (eye worm)	STAT protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Echinococcus granulosus	expressed conserved protein	0.0476	0.3154	0.3154
Schistosoma mansoni	tensin	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Schistosoma mansoni	nck2/grb4	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0802	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0802	1	1
Echinococcus multilocularis	SH2 motif	0.0476	0.3154	0.3154
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Onchocerca volvulus		0.0476	0.3154	0.3154
Brugia malayi	hypothetical protein	0.0802	1	1
Brugia malayi	Tensin	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Onchocerca volvulus		0.0802	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0326	0	0.5
Onchocerca volvulus		0.0802	1	1
Plasmodium falciparum	protein kinase, putative	0.0326	0	0.5
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0802	1	1
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0802	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0802	1	1
Trichomonas vaginalis	STE family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0476	0.3154	0.3154
Toxoplasma gondii	protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0802	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0802	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Giardia lamblia	Kinase, NEK	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0476	0.3154	0.3154
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0476	0.3154	0.3154
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.3154	0.3154
Entamoeba histolytica	protein kinase, putative	0.0476	0.3154	0.3154
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0802	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Echinococcus granulosus	NCK adaptor protein	0.0476	0.3154	0.3154
Echinococcus granulosus	N chimaerin	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0802	1	1
Brugia malayi	Protein kinase domain containing protein	0.0802	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0326	0	0.5
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0476	0.3154	0.3154
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0802	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.3154	0.3154
Loa Loa (eye worm)	SH2 domain-containing protein	0.0476	0.3154	0.3154
Brugia malayi	Variant SH3 domain containing protein	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0476	0.3154	0.3154
Echinococcus granulosus	SH2 domain containing protein 7	0.0476	0.3154	0.3154
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0802	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0326	0	0.5
Giardia lamblia	Kinase	0.0326	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.0476	0.3154	0.3154
Giardia lamblia	Protein 21.1	0.0326	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	N chimaerin	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0476	0.3154	0.3154
Echinococcus granulosus	growth factor receptor bound protein 2	0.0476	0.3154	0.3154
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0476	0.3154	0.3154
Echinococcus multilocularis	SHC transforming protein 3	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0802	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0476	0.3154	0.3154
Echinococcus granulosus	SHC transforming protein 3	0.0476	0.3154	0.3154
Brugia malayi	SH2 domain containing protein	0.0476	0.3154	0.3154
Trypanosoma cruzi	protein kinase, putative	0.0326	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0802	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0802	1	1
Plasmodium falciparum	protein kinase, putative	0.0326	0	0.5
Echinococcus multilocularis	SH2 motif	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0476	0.3154	0.3154
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0802	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0476	0.3154	0.3154
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0476	0.3154	0.3154
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0476	0.3154	0.3154
Trypanosoma brucei	protein kinase, putative	0.0326	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0476	0.3154	0.3154
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	tensin	0.0476	0.3154	0.3154
Trypanosoma brucei	Pseudokinase, putative	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0802	1	1
Echinococcus granulosus	hypothetical protein	0.0476	0.3154	0.3154
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0476	0.3154	0.3154
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0476	0.3154	0.3154
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	AGC family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	SRC-1	0.0802	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0476	0.3154	0.3154
Onchocerca volvulus		0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	hypothetical protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Brugia malayi	SH2 domain containing protein	0.0802	1	1
Schistosoma mansoni	tensin	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0326	0	0.5
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0476	0.3154	0.3154
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0802	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0802	1	1
Schistosoma mansoni	vav2	0.0476	0.3154	0.3154
Brugia malayi	SRC-1	0.0802	1	1
Loa Loa (eye worm)	hypothetical protein	0.0802	1	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0802	1	1
Loa Loa (eye worm)	hypothetical protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Echinococcus multilocularis	tensin	0.0476	0.3154	0.3154
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Toxoplasma gondii	STE kinase	0.0326	0	0.5
Schistosoma mansoni	hypothetical protein	0.0476	0.3154	0.3154
Trichomonas vaginalis	TKL family protein kinase	0.0326	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0802	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.27 uM	Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase	ChEMBL.	23886302
Ki (binding)	= 0.351 uM	Inhibition of human glutaminyl cyclase expressed in Escherichia coli DH5alpha using H-Gln-AMC as substrate by fluorometric analysis in presence of pyroglutamyl aminopeptidase	ChEMBL.	23886302

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418799

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1768936