Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | solute carrier family 6 (neurotransmitter transporter, GABA), member 1 | 599 aa | 605 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0141 | 0.4273 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0141 | 0.4273 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0141 | 0.4273 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0141 | 0.4273 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0141 | 0.4273 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0141 | 0.4273 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.4273 | 0.4273 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0141 | 0.4273 | 0.5 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0141 | 0.4273 | 0.4273 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0253 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0141 | 0.4273 | 0.1427 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0141 | 0.4273 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0141 | 0.4273 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0141 | 0.4273 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0141 | 0.4273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0141 | 0.4273 | 0.1427 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0141 | 0.4273 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0253 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0141 | 0.4273 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0141 | 0.4273 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0141 | 0.4273 | 0.1427 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0141 | 0.4273 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0141 | 0.4273 | 0.1427 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0141 | 0.4273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.332 | 0.332 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.332 | 0.332 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0141 | 0.4273 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0141 | 0.4273 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 51 % | Inhibition of mouse GAT2-mediated [3H]GABA uptake stably transfected in HEK293 cells assessed as residual uptake at 100 uM relative to control | ChEMBL. | 23859778 |
Activity (binding) | = 55 % | Binding affinity to mouse GAT1 stably transfected in HEK293 cells assessed as residual binding at 100 uM relative to control | ChEMBL. | 23859778 |
IC50 (binding) | = 4.38 | Inhibition of mouse GAT3-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
IC50 (binding) | = 4.88 | Inhibition of mouse GAT1-mediated [3H]GABA uptake stably transfected in HEK293 cells | ChEMBL. | 23859778 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.