Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0894 | 1 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.014 | 0.0928 | 0.0682 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0339 | 0.0031 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0841 | 0.9364 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0841 | 0.9364 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.014 | 0.0928 | 0.0991 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.014 | 0.0928 | 0.0682 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0091 | 0.0339 | 0.0362 |
Entamoeba histolytica | casein kinase, putative | 0.0841 | 0.9364 | 0.5 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0388 | 0.3915 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0339 | 0.0031 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0339 | 0.0031 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0091 | 0.0339 | 0.0362 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0841 | 0.9364 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0841 | 0.9364 | 0.5 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0388 | 0.3915 | 0.5 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0388 | 0.3915 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0841 | 0.9364 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0841 | 0.9364 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0841 | 0.9364 | 1 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0091 | 0.0339 | 0.0031 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.014 | 0.0928 | 0.0991 |
Schistosoma mansoni | protein kinase | 0.0841 | 0.9364 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0091 | 0.0339 | 0.0362 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0841 | 0.9364 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0339 | 0.0031 |
Echinococcus granulosus | single minded 2 | 0.0089 | 0.031 | 0.0331 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0091 | 0.0339 | 0.0362 |
Brugia malayi | Casein kinase II, alpha chain | 0.0841 | 0.9364 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0091 | 0.0339 | 0.0031 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0388 | 0.3915 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0841 | 0.9364 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0841 | 0.9364 | 1 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0138 | 0.0899 | 0.0899 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0841 | 0.9364 | 0.5 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0388 | 0.3915 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.0339 | 0.0031 |
Plasmodium vivax | unspecified product | 0.0841 | 0.9364 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0339 | 0.0339 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0841 | 0.9364 | 0.9364 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Mutagenicity in Swiss albino mouse at 100 mg/kg after 30 hrs by micronucleus test | ChEMBL. | 23851115 | |
Activity (ADMET) | Mutagenicity in Swiss albino mouse at 250 mg/kg after 30 hrs by micronucleus test | ChEMBL. | 23851115 | |
IC50 (functional) | = 37.7 uM | Trypanocidal activity against epimastigote stage of Trypanosoma cruzi Y after 72 hrs by MTT assay | ChEMBL. | 23851115 |
Inhibition (binding) | = 10 % | Inhibition of Trypanosoma cruzi cruzain expressed in Escherichia coli DH5-alpha using Bz-Phe-Arg-AMC as substrate at 10 uM preincubated for 5 mins followed by substrate addition measured for 5 mins by spectrofluorimetric analysis relative to control | ChEMBL. | 23851115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.