Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0772 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.1118 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0696 | 0.0343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0696 | 0.0654 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0772 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.0993 | 0.8837 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0662 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0045 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0696 | 0.0343 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0696 | 0.0696 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0662 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0662 | 0.062 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.0993 | 0.8837 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0365 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0696 | 0.0654 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.0993 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0045 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0045 | 0.0045 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.0993 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0372 | 0.0328 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0696 | 0.0696 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.0365 | 0.2985 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0372 | 0.0328 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0662 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0772 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0365 | 1 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0772 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.1118 | 1 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0772 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0365 | 0.0365 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0696 | 0.0654 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0365 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0696 | 0.0654 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0696 | 0.0343 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0365 | 0.5192 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0045 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0696 | 0.0654 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0365 | 0.0365 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0365 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0696 | 0.0654 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0365 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0696 | 0.0654 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.0993 | 0.8837 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0662 | 0.062 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.1118 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0045 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0365 | 0.5192 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0365 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0045 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0696 | 0.0696 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0662 | 0.062 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.1118 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0662 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0662 | 0.062 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.0993 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0045 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0045 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0662 | 0.575 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0662 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 1 % | Displacement of [3H]ZM 241385 from human adenosine A2A receptor expressed in CHO cells at 10 uM after 60 mins by scintillation counting | ChEMBL. | 23911855 |
Inhibition (binding) | = 2 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells at 10 uM after 60 mins by scintillation counting | ChEMBL. | 23911855 |
Inhibition (binding) | = 5 % | Displacement of [3H]MRE-3008-F20 from human adenosine A3 receptor expressed in CHO cells at 10 uM after 60 mins by scintillation counting | ChEMBL. | 23911855 |
Inhibition (functional) | = 46 % | Allosteric enhancement of human adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production at 10 uM after 10 mins | ChEMBL. | 23911855 |
Inhibition (binding) | = 47 % | Allosteric enhancement of human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CCPA-induced cAMP production at 100 nM after 10 mins | ChEMBL. | 23911855 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.