Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.027 | 0.027 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0784 | 1 | 1 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0033 | 0.027 | 0.027 |
Plasmodium vivax | unspecified product | 0.0784 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0784 | 1 | 0.5 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0033 | 0.027 | 0.027 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.027 | 0.027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0033 | 0.027 | 0.027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0033 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.027 | 0.027 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0784 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0784 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.027 | 0.027 |
Schistosoma mansoni | protein kinase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Onchocerca volvulus | 0.0335 | 0.419 | 1 | |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0784 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.027 | 0.027 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.027 | 0.027 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0784 | 1 | 0.5 |
Echinococcus granulosus | single minded 2 | 0.0033 | 0.027 | 0.027 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0033 | 0.027 | 0.027 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0033 | 0.027 | 0.027 |
Echinococcus granulosus | voltage gated potassium channel | 0.0033 | 0.027 | 0.027 |
Entamoeba histolytica | casein kinase, putative | 0.0784 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0335 | 0.419 | 0.419 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0033 | 0.027 | 0.027 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0784 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0784 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0784 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0784 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0784 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0784 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0033 | 0.027 | 0.027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.092 uM | Antagonist activity at human PPARdelta assessed as effect on TIPP-703-induced activity | ChEMBL. | 23891183 |
Inhibition (binding) | = 23.3 % | Antagonist activity at human PPARalpha assessed as effect on TIPP-703-induced activity at 10 uM | ChEMBL. | 23891183 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.