Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4044 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.4044 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.4044 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.4044 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.4044 | 1 | 1 |
Onchocerca volvulus | Kinase homolog | 0.033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 100 uM | Cytotoxicity against human MT4 cells after 4 days by MTT assay | ChEMBL. | 23916148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.