Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 14 uM | Antiparasitic activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as parasite growth inhibition after 48 hrs by [3H]-hypoxanthine incorporation assay | ChEMBL. | 23916149 |
Ki (binding) | = 49 uM | Inhibition of recombinant human dUTPase expressed in Escherichia coli BL21 (DE3) using dUTP as substrate by spectrophotometric analysis | ChEMBL. | 23916149 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 23916149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.