Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3806 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.3806 | 1 | 1 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.3806 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3806 | 1 | 1 |
Onchocerca volvulus | Kinase homolog | 0.0316 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.3806 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 75.88 % | Induction of apoptosis in human 8305C cells assessed as caspase-3 activation at 50 uM after 24 hrs by fluorescence microscopic analysis (Rvb = 3.22 +/- 1%) | ChEMBL. | 23916151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.