Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.071 | 0.2644 | 0.3601 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0418 | 0.0811 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.092 | 0.0468 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0645 | 0.2232 | 0.2806 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0801 | 0.3214 | 0.4706 |
Schistosoma mansoni | serine/threonine protein kinase | 0.071 | 0.2644 | 0.202 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.085 | 0.3519 | 0.5294 |
Trichomonas vaginalis | AGC family protein kinase | 0.071 | 0.2644 | 0.3601 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0801 | 0.3214 | 0.2616 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0414 | 0.0782 | 0.5 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.1237 | 0.5951 | 1 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0801 | 0.3214 | 0.2616 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.071 | 0.2644 | 0.2661 |
Brugia malayi | Protein kinase domain containing protein | 0.071 | 0.2644 | 0.3601 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.1237 | 0.5951 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0418 | 0.0811 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0801 | 0.3214 | 0.3387 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1237 | 0.5951 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.071 | 0.2644 | 0.2661 |
Entamoeba histolytica | hypothetical protein | 0.0984 | 0.4365 | 0.6931 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1629 | 0.8414 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.1237 | 0.5951 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0597 | 0.1932 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.071 | 0.2644 | 0.1994 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.071 | 0.2644 | 0.3601 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.1237 | 0.5951 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.1201 | 0.5721 | 0.9555 |
Trichomonas vaginalis | AGC family protein kinase | 0.071 | 0.2644 | 0.3601 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1882 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0418 | 0.0811 | 0.033 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.071 | 0.2644 | 0.1994 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.1237 | 0.5951 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0549 | 0.1628 | 0.1637 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1882 | 1 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0418 | 0.0811 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.085 | 0.3519 | 0.5294 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0447 | 0.0991 | 0.0227 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0414 | 0.0782 | 0.0426 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0984 | 0.4365 | 0.6931 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.1237 | 0.5951 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.071 | 0.2644 | 0.3601 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 6000 nM | Inhibition of porcine DPP4 assessed as residual enzyme activity using H-Gly-Pro-AMC as substrate by fluorescence assay | ChEMBL. | 24900744 |
Activity (binding) | = 7000 nM | Inhibition of human DPP4 assessed as residual enzyme activity using H-Gly-Pro-AMC as substrate by fluorescence assay | ChEMBL. | 24900744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.