Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0404 | 0.5075 | 0.2202 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0404 | 0.5075 | 0.2202 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0628 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0404 | 0.5075 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0404 | 0.5075 | 0.2202 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0404 | 0.5075 | 0.2202 |
Trypanosoma brucei | Casein kinase II | 0.0628 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Trypanosoma cruzi | casein kinase II, putative | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0404 | 0.5075 | 0.2202 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0404 | 0.5075 | 0.2202 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0404 | 0.5075 | 0.2202 |
Leishmania major | casein kinase II, putative | 0.0628 | 1 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0628 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0628 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0628 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0628 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0404 | 0.5075 | 0.2202 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0404 | 0.5075 | 0.5075 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0628 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0404 | 0.5075 | 0.2202 |
Giardia lamblia | Kinase, PLK | 0.0404 | 0.5075 | 0.2202 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Schistosoma mansoni | kinase | 0.0371 | 0.4328 | 0.1018 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0628 | 1 | 1 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0404 | 0.5075 | 0.2202 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Trichomonas vaginalis | casein kinase II beta chain, putative | 0.0341 | 0.3684 | 0.3684 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 12 uM | Antiproliferative activity against human HCC1954 cells assessed as growth inhibition after 5 days by SRB assay | ChEMBL. | 23829549 |
IC50 (binding) | = 2 nM | Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ELISA assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.