Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0165 | 0.0386 | 0.0386 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.3753 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0706 | 0.1836 | 0.1836 |
Schistosoma mansoni | protein kinase | 0.3753 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3753 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0165 | 0.0386 | 0.0386 |
Schistosoma mansoni | kinase | 0.0165 | 0.0386 | 0.0386 |
Onchocerca volvulus | Kinase homolog | 0.0165 | 0.0386 | 1 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0165 | 0.0386 | 0.0386 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.3753 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0165 | 0.0386 | 0.0386 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.3753 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.