Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hypoxanthine phosphoribosyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0111 | 0.0132 | 0.0151 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0871 | 0.4003 | 1 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0871 | 0.4003 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2049 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0871 | 0.4003 | 1 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0111 | 0.0132 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0871 | 0.4003 | 0.035 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0111 | 0.0132 | 0.0151 |
Trypanosoma brucei | Casein kinase II | 0.0871 | 0.4003 | 1 |
Onchocerca volvulus | 0.0828 | 0.3785 | 0.3702 | |
Plasmodium vivax | unspecified product | 0.0871 | 0.4003 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0871 | 0.4003 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.2049 | 1 | 1 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0085 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0871 | 0.4003 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0871 | 0.4003 | 0.5 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0111 | 0.0132 | 0.0151 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.2049 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2049 | 1 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0871 | 0.4003 | 0.3923 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0085 | 0 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0871 | 0.4003 | 1 |
Schistosoma mansoni | protein kinase | 0.0871 | 0.4003 | 0.3923 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0871 | 0.4003 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0871 | 0.4003 | 0.3923 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.2049 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.2049 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.2049 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0871 | 0.4003 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0871 | 0.4003 | 0.3923 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11320 nM | Inhibition of human HGPRT using xanthine/PRPP assessed as xanthine/guanine conversion to xanthosine-5'-monophosphate/guanosine-5'-monophosphate by spectrophotometry in presence of PRPP | ChEMBL. | 23810424 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.