Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0109 | 0.0255 | 0.0255 |
Trypanosoma brucei | Casein kinase II | 0.0831 | 0.4411 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0657 | 0.3409 | 0.3409 |
Plasmodium vivax | unspecified product | 0.0831 | 0.4411 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0831 | 0.4411 | 0.5 |
Mycobacterium leprae | Possible transporter protein | 0.0065 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0831 | 0.4411 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.1801 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase 7 | 0.0122 | 0.0328 | 0.0328 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0831 | 0.4411 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0122 | 0.0328 | 0.0328 |
Echinococcus multilocularis | kinase protein | 0.0122 | 0.0328 | 0.0328 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.1801 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.1801 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0831 | 0.4411 | 0.4411 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.1801 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0831 | 0.4411 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Schistosoma mansoni | protein kinase | 0.0831 | 0.4411 | 0.4411 |
Brugia malayi | Protein kinase domain containing protein | 0.0109 | 0.0255 | 0.0255 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0831 | 0.4411 | 0.4411 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1801 | 1 | 1 |
Echinococcus granulosus | 5'partial|3'partial|mitogen activated protein kinase kinase kinase | 0.0122 | 0.0328 | 0.0328 |
Echinococcus multilocularis | kinase protein | 0.0122 | 0.0328 | 0.0328 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0831 | 0.4411 | 1 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0831 | 0.4411 | 0.5 |
Brugia malayi | Casein kinase II, alpha chain | 0.0831 | 0.4411 | 0.4411 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0122 | 0.0328 | 0.0328 |
Echinococcus granulosus | 3'partial|mitogen activated protein kinase kinase kinase | 0.0122 | 0.0328 | 0.0328 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1801 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0831 | 0.4411 | 0.4411 |
Loa Loa (eye worm) | TKL/MLK/TAK1 protein kinase | 0.0109 | 0.0255 | 0.0255 |
Leishmania major | casein kinase II, putative | 0.0831 | 0.4411 | 0.5 |
Trypanosoma cruzi | casein kinase II, putative | 0.0831 | 0.4411 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.1801 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0109 | 0.0255 | 0.0255 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0122 | 0.0328 | 0.0328 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0831 | 0.4411 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP | ChEMBL. | 23850198 |
IC50 (binding) | = 1.2 uM | Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylation | ChEMBL. | 23850198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.