Detailed view for EmuJ_001202000

Basic information

TDR Targets ID: 959344
Echinococcus multilocularis, kinase protein
Source Database / ID:  GeneDB

pI: 8.0428 | Length (AA): 162 | MW (Da): 18256 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 161 5vam (A) 491 628 37.00 0 0.61 1.12148 0.93
10 132 2pzi (A) 195 297 31.00 0.18 0.73 0.786459 0.58
12 131 4uya (A) 170 307 46.00 0.00000000006 1 0.943941 0.69
84 161 2z7q (A) 164 237 53.00 0.000079 0.54 0.668682 1.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132679)

Species Accession Gene Product
Brugia malayi Bm1_26085   Protein kinase domain containing protein
Caenorhabditis elegans CELE_Y105C5A.24   Protein Y105C5A.24
Caenorhabditis elegans CELE_F52F12.3   Protein MOM-4
Drosophila melanogaster Dmel_CG18492   TGF-beta activated kinase 1
Echinococcus granulosus EgrG_000918100   5'partial|3'partial|mitogen activated protein kinase kinase kinase
Echinococcus granulosus EgrG_000623200   mitogen activated protein kinase kinase kinase
Echinococcus granulosus EgrG_000679500   3'partial|mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000623200   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_001202000   kinase protein
Echinococcus multilocularis EmuJ_001201700   kinase protein
Echinococcus multilocularis EmuJ_000679900   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000679500   mitogen activated protein kinase kinase kinase 7
Echinococcus multilocularis EmuJ_000679000   mitogen activated protein kinase kinase kinase
Echinococcus multilocularis EmuJ_000918100   mitogen activated protein kinase kinase kinase
Homo sapiens ENSG00000135341   mitogen-activated protein kinase kinase kinase 7
Loa Loa (eye worm) LOAG_02503   TKL/MLK/TAK1 protein kinase
Mus musculus ENSMUSG00000028284   mitogen-activated protein kinase kinase kinase 7
Schmidtea mediterranea mk4.001525.00   Protein kinase

Essentiality

EmuJ_001202000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F52F12.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0571 0.9772 0.9772
0.0087 0.7279 0.9624
0.0108 0.9693 0.9693
0.0106 0.9673 0.9673
0.0555 0.9754 0.9754
0.0288 0.655 0.6376
0.0587 0.9848 0.9848
0.0108 0.9693 0.9693
0.0536 0.8973 0.8973
0.1584 0.9746 0.9746
0.3738 0.9765 0.9764
0.1101 0.6549 0.6548
0.0108 0.9693 0.9693
0.0088 0.9722 0.9722
0.0092 1 1
0.0108 0.9693 0.9693
0.3738 0.9765 0.9764
0.2039 0.976 0.976
0.0106 0.7888 0.7888
0.0099 0.9869 0.9869
0.0371 0.9693 0.9693
0.0016 0.5 0.5
0.361 0.976 0.976
0.0802 0.9687 0.9621
0.0183 0.3702 0.3702
0.0036 0.5 0.5
0.1557 0.2824 0.2824
0.0063 1 1
0.0191 0.9381 0
0.1557 0.2824 0.2824
0.0107 0.9381 0
0.0107 0.9381 0
0.0089 0.2944 0.9624
0.1557 0.2824 0.2824
0.0089 0.3549 0.9623
0.3396 0.9607 0.9607
0.0081 1 1
0.0189 0.9745 0.9745
0.0273 0.3518 0.9761
0.1557 0.2824 0.2824
0.0101 0.9759 0.9759
0.2231 0.9764 0.976
0.0444 0.5158 0.5158
0.0095 0.2951 0.9703
0.0107 0.9381 0
0.0106 0.9741 0.9741
0.0092 0.4013 0.4013
0.0106 0.3945 0.3945
0.0106 0.974 0.974
0.0039 0.5 0.5
0.3531 0.9765 0.9765
0.0091 1 1
0.0107 0.5626 0.9709
0.3151 0.5739 0.5712
0.0279 0.9693 0.9693
0.1008 0.9757 0.9757
0.1022 0.8072 0.8072
0.0197 0.9299 0.9299
0.0553 0.6799 0.6799
0.0562 0.9772 0.9772
0.3273 0.9759 0.9759
0.255 0.9764 0.9764
0.0738 0.9846 0.9846
0.0018 0.5 0.5
0.0448 0.9742 0.9742
0.3612 0.9765 0.9765
0.0101 0.9713 0.9713
0.0003 0.5 0.5
0.0056 1 1
0.0106 0.9515 0
0.0108 0.9693 0.9693
0.0012 0.5 0.5
0.0839607 0.391353 0.978234
0.0067 0.5 0.5
0.0636 0.4839 0.9546
0.3515 0.9762 0.9762
0.3408 0.9765 0.9765
0.0039 0.5 0.5
0.128 0.976 0.976
0.3408 0.9765 0.9765
0.0007 0.5 0.5
0.1373 0.816 0.8156
0.0102 0.6714 0.6591
0.0093 0.8828 0
0.3372 0.9765 0.9765
0.0464 0.9783 0.9783
0.0561 0.9753 0.9753
0.0022 0.5 0.5
0.0452 0.6198 0.6198
0.0108 0.9693 0.9693
0.0107 0.9811 0.9811
0.2842 0.976 0.976
0.0108 0.9693 0.9693
0.0195 0.5598 0.5585
0.0108 0.9693 0.9693
0.0007 0.5 0.5
0.324 0.976 0.976
0.0106 0.7923 0.7923
0.0066 0.3101 0.9479
0.0106 0.9727 0.9727
0.3408 0.9765 0.9765
0.0187 0.3082 0.9442
0.0106 0.9043 0.9043
0.0107 0.9811 0.9811
0.0282 0.9707 0.9696
0.0104 0.9381 0
0.0011 1 1
0.0111 0.3336 0.3336
0.0757 0.5655 0.5655
0.0012 0.5 0.5
0.0175 0.9381 0
0.1011 0.975 0.975
0.0108 0.9693 0.9693
0.0186 0.9825 0.9825
0.0062 0.6935 0.7231
0.0175 0.7056 0.9737
0.01 0.9739 0.9739
0.2999 0.9761 0.9761
0.1022 0.8072 0.8072
0.0042 0.5 0.5
0.0004 0.5 0.5
0.3396 0.9607 0.9607
0.1584 0.9746 0.9746
0.0089 0.952 0.952
0.0359 0.9737 0.9737
0.0107 0.9811 0.9811
0.1557 0.2824 0.2824
0.1101 0.6549 0.6548
0.1101 0.6549 0.6548
0.2927 0.9763 0.9763
0.0108 0.9693 0.9693
0.1557 0.2824 0.2824
0.1101 0.6549 0.6548
0.0275 0.9693 0.9693
0.0828 0.9745 0.9744
0.0087 0.4936 0.4936
0.0008 0.5 0.5
0.0086 0.5626 0.9709
0.0027 1 1
0.0092 0.3062 0.9736
0.0843 0.9742 0.9742
0.0059 1 1
0.0107 0.9381 0
0.0561 0.976 0.976
0.0032 0.5 0.5
0.0558 0.2611 0.9646
0.0039 0.9485 0.9402
0.1557 0.2824 0.2824
0.009 0.5323 0.5323
0.3255 0.9765 0.9765
0.0843 0.9742 0.9742
0.1373 0.816 0.8156
0.1237 0.9719 0.9677
0.0642 0.4811 0.6407
0.0101 0.9759 0.9759
0.0581 0.9754 0.9754
0.3636 0.9762 0.9762
0.0459 0.9768 0.9768
0.0104 0.9685 0.9492
0.0106 0.524 0.524
0.0534 0.9754 0.9754
0.0301 0.6347 0.6347
0.038 0.9681 0.9681
0.0712 0.9735 0
0.3257 0.9766 0.9766
0.0108 0.9693 0.9693
0.0098 0.3242 0.2282
0.0088 0.4477 0.4477
0.1107 0.9739 0.9707
0.3515 0.9762 0.9762
0.1479 0.5427 0.5427
0.0103 0.6881 0.6855
0.3257 0.9766 0.9766
0.1557 0.2824 0.2824
0.0575 0.9754 0.9754
0.0107 0.9811 0.9811
0.059663 0.447504 0.95826
0.1557 0.2824 0.2824
0.3065 0.9762 0.9762
0.0108 0.9693 0.9693
0.0496 0.9742 0.9742
0.3738 0.9765 0.9764
0.0176 0.7227 0.7002
0.0026 0.5 0.5
0.0604 0.603 0.603
0.0032 0.5 0.5
0.0108 0.9693 0.9693
0.0632 0.3627 0.9686
0.3408 0.9765 0.9765
0.0086 0.5792 0.9821
0.0345 0.974 0.974
0.0048 0.4162 0.4162
0.0476 0.9743 0.9743
0.0086 0.5626 0.9709
0.362 0.976 0.976
0.0554 0.767 0.767
0.0744 0.9729 0.9729
0.0828 0.9745 0.9744
0.0724 0.9735 0
0.0029 0.5 0.5
0.361 0.976 0.976
0.0007 0.5 0.5
0.0196 0.6533 0.971
0.0275 0.9746 0.9746
0.1557 0.2824 0.2824
0.0108 0.9693 0.9693
0.0037 1 1
0.0012 0.5 0.5
0.0108 0.9693 0.9693
0.0016 0.5 0.5
0.0064 0.3377 0.9531
0.0642 0.9767 0.9767
0.0287 0.9614 0.9614
0.0069 0.3067 0.3067
0.0345 0.974 0.974
0.0106 0.4854 0
0.1557 0.2824 0.2824
0.1479 0.5427 0.5427
0.0106 0.9757 0.9726
0.0033 1 1
0.0183 0.3199 0.3199
0.0843 0.9742 0.9742
0.3738 0.9765 0.9764
0.3021 0.9764 0.9764
0.3612 0.9765 0.9765
0.3396 0.9607 0.9607
0.0184 0.9693 0.9693
0.3372 0.9765 0.9765
0.3024 0.9765 0.9765
0.0101 0.9722 0.9697
0.0023 0.5 0.5
0.0081 0.5 0.5
0.0301 0.6347 0.6347
0.0107 0.9811 0.9811
0.3738 0.9765 0.9764
0.0496 0.9753 0.9753
0.0033 0.5 0.5
0.3151 0.5739 0.5712
0.0088 1 1
0.3396 0.9607 0.9607
0.0107 0.9812 0.9812
0.0089 0.5934 0.5934
0.1107 0.9739 0.9707
0.0359 0.9737 0.9737
0.3408 0.9765 0.9765
0.0106 0.3945 0.3945
0.0059 1 1
0.0063 0.7244 0
0.0642 0.9767 0.9767
0.3273 0.9759 0.9759
0.0843 0.9742 0.9742
0.0272 0.312 0.3101
0.0437 0.6354 0.9617
0.3065 0.9762 0.9762
0.0107 0.5689 0.9716
0.0061 0.6883 0.6883
0.0361 0.2739 0.3369
0.0059 1 1
0.0757 0.5655 0.5655
0.0553 0.9512 0.9505
0.0107 0.9049 0.9049
0.0092 0.6119 0.9716

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EmuJ_001202000 (Echinococcus multilocularis), kinase protein
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