Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calpain 1, (mu/I) large subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | calpain A | calpain 1, (mu/I) large subunit | 714 aa | 753 aa | 31.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0069 | 0.0647 | 0.0647 |
Trypanosoma cruzi | casein kinase II, putative | 0.0704 | 1 | 1 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0704 | 1 | 1 |
Leishmania major | casein kinase II, putative | 0.0704 | 1 | 1 |
Trypanosoma brucei | Casein kinase II | 0.0704 | 1 | 1 |
Mycobacterium leprae | Possible transporter protein | 0.0054 | 0.0431 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0704 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0048 | 0.0348 | 0.0348 |
Entamoeba histolytica | casein kinase, putative | 0.0704 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/PASK protein kinase | 0.0546 | 0.7668 | 0.7668 |
Echinococcus multilocularis | calpain A | 0.0069 | 0.0647 | 0.0647 |
Plasmodium vivax | unspecified product | 0.0704 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0431 | 0.0431 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0054 | 0.0431 | 0.0431 |
Trypanosoma brucei | STE group serine/threonine-protein kinase, putative | 0.0063 | 0.0556 | 0.0556 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0647 | 0.0647 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0348 | 0.0348 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0054 | 0.0431 | 0.0431 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0704 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0431 | 0.0431 |
Brugia malayi | calpain family protein 1 | 0.0066 | 0.0603 | 0.0603 |
Echinococcus granulosus | single minded 2 | 0.0054 | 0.0431 | 0.0431 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0704 | 1 | 1 |
Onchocerca volvulus | 0.0546 | 0.7668 | 1 | |
Echinococcus granulosus | voltage gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0493 | 0.0493 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0238 | 0.0238 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Schistosoma mansoni | protein kinase | 0.0704 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0647 | 0.0647 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0054 | 0.0431 | 0.0431 |
Brugia malayi | calpain family protein 1 | 0.0066 | 0.0603 | 0.0603 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0054 | 0.0431 | 0.0431 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0704 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0066 | 0.0603 | 0.0603 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0048 | 0.0348 | 0.0348 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0704 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0603 | 0.0603 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0054 | 0.0431 | 0.0431 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0069 | 0.0647 | 0.0647 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0704 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0704 | 1 | 1 |
Echinococcus granulosus | calpain A | 0.0069 | 0.0647 | 0.0647 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0066 | 0.0603 | 0.0603 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0704 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0054 | 0.0431 | 0.0431 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5000 nM | Inhibition FRET Assay | BINDINGDB. | No reference |
IC50 (binding) | = 5 uM | Inhibition of human erythrocyte full length Cal1 using (DABCYL)TPLK-SPPSPR-(EDANS) as substrate after 20 min by FRET assay | ChEMBL. | 23834438 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.