Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.014 | 0.0823 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0043 | 0.0103 | 0.111 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.015 | 0.0897 | 0.0897 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0153 | 0.0925 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0103 | 0.1028 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0103 | 0.1028 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0153 | 0.0925 | 0.0925 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.015 | 0.0897 | 0.9692 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0163 | 0.1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0043 | 0.0103 | 0.111 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0103 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0733 | 0.0733 |
Toxoplasma gondii | hypothetical protein | 0.1367 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0103 | 0.111 |
Brugia malayi | diacylglycerol acyltransferase | 0.0153 | 0.0925 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.1367 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0163 | 0.1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1367 | 1 | 1 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0153 | 0.0925 | 0.9257 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.1367 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0043 | 0.0103 | 0.111 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.014 | 0.0823 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.015 | 0.0897 | 0.9692 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0103 | 0.0103 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0153 | 0.0925 | 0.5 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0153 | 0.0925 | 1 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0153 | 0.0925 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.015 | 0.0897 | 0.9692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 185 nM | Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometry | ChEMBL. | 23871442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.