Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 4 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | polo-like kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | stromal interaction molecule 1 | 0.0819 | 0.1334 | 0.0903 |
Schistosoma mansoni | Protein orai-1 | 0.5042 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.04 | 0.0473 | 0.5 |
Schistosoma mansoni | Protein orai-1 | 0.5042 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.04 | 0.0473 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.04 | 0.0473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0819 | 0.1334 | 0.0903 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.5042 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.04 | 0.0473 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Echinococcus granulosus | calcium release activated calcium channel | 0.5042 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.04 | 0.0473 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 0.0422 | 0.0019 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0444 | 0.0563 | 0.0167 |
Schistosoma mansoni | serine/threonine protein kinase | 0.04 | 0.0473 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0819 | 0.1334 | 0.0903 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.04 | 0.0473 | 0.5 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.0819 | 0.1334 | 0.0903 |
Trichomonas vaginalis | CAMK family protein kinase | 0.04 | 0.0473 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.04 | 0.0473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5042 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 50 uM | Antiproliferative activity against human HCC1954 cells assessed as growth inhibition after 5 days by SRB assay | ChEMBL. | 23829549 |
IC50 (ADMET) | Inhibition of CYP1A2 (unknown origin) using CEC as substrate after 15 mins by fluorescence assay | ChEMBL. | 23829549 | |
IC50 (ADMET) | Inhibition of CYP2C19 (unknown origin) using MFC as substrate after 30 mins by fluorescence assay | ChEMBL. | 23829549 | |
IC50 (ADMET) | Inhibition of CYP3A4 (unknown origin) after 10 mins by fluorescence assay | ChEMBL. | 23829549 | |
IC50 (ADMET) | Inhibition of CYP2C9 (unknown origin) using MFC as substrate after 45 mins by fluorescence assay | ChEMBL. | 23829549 | |
IC50 (ADMET) | Inhibition of CYP2D6 (unknown origin) using AMMC as substrate after 30 mins by fluorescence assay | ChEMBL. | 23829549 | |
IC50 (binding) | = 0.9 nM | Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ELISA assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
IC50 (binding) | > 10 uM | Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay | ChEMBL. | 23829549 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.