Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 1.0305 | 0.2376 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0491 | 0 | 0.5 |
Mycobacterium ulcerans | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 4.1799 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0491 | 0 | 0.5 |
Chlamydia trachomatis | bifunctional 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase | 1.0305 | 0.2376 | 0.5 |
Toxoplasma gondii | dihydropteroate synthase | 1.0305 | 0.2376 | 0.5 |
Leishmania major | methionine synthase, putative | 0.07 | 0.0051 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0 | 0.5 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 1.0305 | 0.2376 | 0.5 |
Mycobacterium tuberculosis | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) ( | 3.2195 | 0.7675 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 60 % | Inhibition of human beta-glucocerebrosidase at 20 uM by fluorescence spectrophotometry | ChEMBL. | 23880081 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.