Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 5 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 3 | Starlite/ChEMBL | References |
Homo sapiens | potassium inwardly-rectifying channel, subfamily J, member 6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0368 | 0.0986 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0306 | 0.0646 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.034 | 0.0833 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0368 | 0.0986 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.2014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.0986 | 0.0986 |
Echinococcus granulosus | acetylcholinesterase | 0.2014 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2014 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2014 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Onchocerca volvulus | 0.034 | 0.0833 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.0646 | 0.0646 |
Echinococcus multilocularis | acetylcholinesterase | 0.2014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.0646 | 0.0646 |
Onchocerca volvulus | 0.034 | 0.0833 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Onchocerca volvulus | 0.034 | 0.0833 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.2014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.0646 | 0.0646 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.034 | 0.0833 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2014 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.034 | 0.0833 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.034 | 0.0833 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Loa Loa (eye worm) | carboxylesterase | 0.2014 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.034 | 0.0833 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.034 | 0.0833 | 0.5 |
Onchocerca volvulus | 0.034 | 0.0833 | 0.5 | |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0306 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.0833 | 0.0833 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2014 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.034 | 0.0833 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0368 | 0.0986 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.034 | 0.0833 | 0.0833 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0368 | 0.0986 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2014 | 1 | 1 |
Onchocerca volvulus | 0.034 | 0.0833 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.21 uM | Activation of GIRK1/2 (unknown origin) | ChEMBL. | 23838260 |
EC50 (binding) | = 0.32 uM | Activation of GIRK1/4 (unknown origin) | ChEMBL. | 23838260 |
Efficacy (binding) | = 47 % | Activation of GIRK1/2 (unknown origin) relative to ML297 | ChEMBL. | 23838260 |
Efficacy (binding) | = 83 % | Activation of GIRK1/4 (unknown origin) relative to ML297 | ChEMBL. | 23838260 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.