Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0293 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0423 | 1 | 1 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0423 | 1 | 0.5 |
Onchocerca volvulus | 0.0423 | 1 | 0.5 | |
Loa Loa (eye worm) | WD40 repeat protein | 0.0423 | 1 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.032 | 0.205 | 0.5 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.032 | 0.205 | 0.5 |
Echinococcus granulosus | protein will die slowly | 0.0423 | 1 | 0.5 |
Echinococcus multilocularis | protein will die slowly | 0.0423 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.