Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | shaker cognate | potassium voltage-gated channel, shaker-related subfamily, member 3 | 575 aa | 465 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.9678 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0104 | 0.0478 | 0.0478 |
Schistosoma mansoni | hypothetical protein | 0.0446 | 0.7801 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0096 | 0.0304 | 0.0304 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.0304 | 0.0304 |
Brugia malayi | PAS domain containing protein | 0.011 | 0.0611 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.6147 | 0.6233 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 0.0478 | 0.0478 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.0478 | 0.0233 |
Echinococcus granulosus | jun protein | 0.0549 | 1 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.034 | 0.5536 | 0.5536 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.0381 | 0.0381 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0549 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.0304 | 0.0304 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 0.0478 | 0.0478 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 0.0478 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0478 | 0.0186 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0549 | 1 | 1 |
Onchocerca volvulus | 0.0431 | 0.7479 | 1 | |
Echinococcus multilocularis | jun protein | 0.0549 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0446 | 0.7801 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0081 | 0 | 0.5 |
Schistosoma mansoni | single-minded | 0.011 | 0.0611 | 0.041 |
Brugia malayi | hypothetical protein | 0.0431 | 0.7479 | 0.7479 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0096 | 0.0304 | 0.0304 |
Brugia malayi | hypothetical protein | 0.0369 | 0.6147 | 0.6147 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.034 | 0.5536 | 0.5581 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.011 | 0.0611 | 0.041 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.0478 | 0.0478 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0096 | 0.0304 | 0.0304 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 99 nM | Inhibition of DiTc binding to Kv1.3 channel in human brain membranes | ChEMBL. | 12643934 |
IC50 (binding) | = 99 nM | Inhibition of DiTc binding to Kv1.3 channel in human brain membranes | ChEMBL. | 12643934 |
IC50 (binding) | = 104 nM | Inhibition of DiTc binding to Kv1.x channel in human brain membranes | ChEMBL. | 12643934 |
IC50 (functional) | = 150 nM | Inhibition of [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel | ChEMBL. | 12643934 |
IC50 (functional) | = 150 nM | Inhibition of [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel | ChEMBL. | 12643934 |
IC50 (functional) | = 1255 nM | Inhibition of T-cell proliferation was determined by a human T-cell assay | ChEMBL. | 12643934 |
IC50 (functional) | = 1255 nM | Inhibition of T-cell proliferation was determined by a human T-cell assay | ChEMBL. | 12643934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.