Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0774 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0774 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0672 | 0 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0672 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0774 | 1 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0774 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 23 uM after 30 mins by spectrophotometric analysis | ChEMBL. | 23796767 | |
Inhibition (functional) | Antibacterial activity against Escherichia coli ATCC 25922 at 50 ug/ml after 24 hrs by agar well diffusion method | ChEMBL. | 23796767 | |
Inhibition (functional) | = 40 % | Antibacterial activity against Candida albicans ATCC 10231 at 50 ug/ml after 24 hrs by agar well diffusion method relative to nystatine | ChEMBL. | 23796767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.