Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.1483 | 0.1702 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1088 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.1088 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.1088 | 0.0755 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.1088 | 0.0755 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.1088 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.1088 | 0.0755 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1088 | 0.0755 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.1088 | 0.0755 | 0.5 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0772 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.4948 | 1 | 0.5 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.1483 | 0.1702 | 1 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.4633 | 0.9245 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.1088 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Giardia lamblia | Hypothetical protein | 0.1088 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.1088 | 0.0755 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.1483 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Schistosoma mansoni | biotin-protein ligase | 0.1483 | 0.1702 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1483 | 0.1702 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.