Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ATP-dependent phosphofructokinase | 0.0111 | 0.6261 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.003 | 0.0735 | 1 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.003 | 0.0735 | 0.1175 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0111 | 0.6261 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.003 | 0.0735 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.003 | 0.0735 | 1 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0111 | 0.6261 | 0.6884 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.9095 | 0.9095 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0111 | 0.6261 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0111 | 0.6261 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.0735 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0111 | 0.6261 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0111 | 0.6261 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.0735 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0111 | 0.6261 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.9095 | 0.9095 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.9095 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.9095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0111 | 0.6261 | 1 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0166 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.003 | 0.0735 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0111 | 0.6261 | 0.5 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0111 | 0.6261 | 0.6884 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.9095 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.003 | 0.0735 | 0.1175 |
Brugia malayi | phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.003 | 0.0735 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.9095 | 0.9095 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.003 | 0.0735 | 0.1175 |
Toxoplasma gondii | 6-phosphofructokinase | 0.003 | 0.0735 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.003 | 0.0735 | 1 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.003 | 0.0735 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0111 | 0.6261 | 0.6261 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0111 | 0.6261 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 73.1 nM | Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as inhibition of calcium mobilization by FLIPR assay | ChEMBL. | 23591110 |
Inhibition (functional) | = 94 % | Antagonist activity at human histamine H3 receptor in human T-REx-293 cells assessed as inhibition of basal GTPgammaS binding at 10 uM after 90 mins by scintillation counting analysis relative to control | ChEMBL. | 23591110 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.