Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 8 (neutrophil collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 7 (matrilysin, uterine) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 12 (macrophage elastase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 7 (matrilysin, uterine) | 267 aa | 234 aa | 41.0 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 12 (macrophage elastase) | 470 aa | 467 aa | 32.1 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 8 (neutrophil collagenase) | 467 aa | 467 aa | 33.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0311 | 0.5205 | 0.6023 |
Schistosoma mansoni | hypothetical protein | 0.0199 | 0.1591 | 0.2577 |
Echinococcus granulosus | plexin a4 | 0.0404 | 0.8183 | 0.7367 |
Onchocerca volvulus | 0.0341 | 0.6175 | 1 | |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0246 | 0.3099 | 0.5 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0171 | 0.0697 | 0.5 |
Brugia malayi | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.3787 |
Brugia malayi | Matrixin family protein | 0.029 | 0.4509 | 0.551 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0311 | 0.5205 | 0.843 |
Echinococcus multilocularis | plexin a4 | 0.0404 | 0.8183 | 0.7367 |
Schistosoma mansoni | plexin | 0.0341 | 0.6175 | 1 |
Loa Loa (eye worm) | plexin A | 0.0404 | 0.8183 | 1 |
Brugia malayi | plexin A | 0.0404 | 0.8183 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0246 | 0.3099 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0246 | 0.3099 | 0.3209 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0311 | 0.5205 | 0.843 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0246 | 0.3099 | 0.5 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0246 | 0.3099 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0171 | 0.0697 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6175 | 0.7317 |
Schistosoma mansoni | plexin | 0.0199 | 0.1591 | 0.2577 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0171 | 0.0697 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.029 | 0.4509 | 0.5092 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0246 | 0.3099 | 0.5018 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0171 | 0.0697 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.1591 | 0.1195 |
Brugia malayi | Plexin repeat family protein | 0.0341 | 0.6175 | 0.7546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.0611 uM | Binding affinity to MMP12 (unknown origin) | ChEMBL. | No reference |
Ki (binding) | = 42 nM | Inhibition of MMP13 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | ChEMBL. | 24900710 |
Ki (binding) | = 62 nM | Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | ChEMBL. | 24900710 |
Ki (binding) | = 240 nM | Inhibition of MMP8 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | ChEMBL. | 24900710 |
Ki (binding) | = 3400 nM | Inhibition of MMP1 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | ChEMBL. | 24900710 |
Ki (binding) | = 4000 nM | Inhibition of MMP7 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assay | ChEMBL. | 24900710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.