Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4045 | 0.383 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Schistosoma mansoni | adenylate cyclase | 0.0089 | 0.0348 | 0.0653 |
Echinococcus multilocularis | GPCR, family 2 | 0.0327 | 0.227 | 0.3602 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0827 | 0.6303 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0707 | 0.5332 | 0.6539 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0327 | 0.227 | 0.1991 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0327 | 0.227 | 0.2522 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0707 | 0.5333 | 0.8461 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0327 | 0.227 | 0.3602 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0513 | 0.0171 |
Onchocerca volvulus | 0.0547 | 0.4045 | 0.041 | |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.0513 | 0.0217 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0707 | 0.5333 | 0.5165 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0131 | 0.0689 | 0.1292 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0547 | 0.4045 | 0.6418 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1034 | 0.797 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0327 | 0.227 | 0.2522 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.227 | 0.1991 |
Schistosoma mansoni | hypothetical protein | 0.0707 | 0.5332 | 0.9998 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0131 | 0.0689 | 0.1292 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0547 | 0.4045 | 0.6418 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1212 | 0.9405 | 1 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0131 | 0.0689 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1034 | 0.797 | 1 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0327 | 0.227 | 0.3602 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0327 | 0.227 | 0.3602 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0547 | 0.4045 | 0.041 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0327 | 0.227 | 0.3602 |
Brugia malayi | Adenylyl cyclase protein | 0.0547 | 0.4045 | 0.485 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0131 | 0.0689 | 0.5 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0131 | 0.0689 | 0.5 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0827 | 0.6303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1184 | 0.9176 | 0.9146 |
Loa Loa (eye worm) | hypothetical protein | 0.1034 | 0.797 | 0.7897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1034 | 0.797 | 0.7897 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0707 | 0.5333 | 1 |
Schistosoma mansoni | adenylate cyclase | 0.0089 | 0.0348 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0707 | 0.5332 | 0.5164 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0707 | 0.5333 | 0.8461 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0707 | 0.5333 | 0.654 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0327 | 0.227 | 0.3602 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (binding) | = 5 uM | Inhibition of Staphylococcus aureus DNA gyrase assessed as inhibition of negative supercoiling of pBR322 DNA after 30 mins by agarose gel electrophoresis | ChEMBL. | 26320664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.