Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0547 | 0.4045 | 0.041 | |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.0513 | 0.0217 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0707 | 0.5333 | 0.5165 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0131 | 0.0689 | 0.1292 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0547 | 0.4045 | 0.6418 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4045 | 0.383 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Schistosoma mansoni | adenylate cyclase | 0.0089 | 0.0348 | 0.0653 |
Echinococcus multilocularis | GPCR, family 2 | 0.0327 | 0.227 | 0.3602 |
Echinococcus granulosus | adenylate cyclase type IX | 0.0827 | 0.6303 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0707 | 0.5332 | 0.6539 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0327 | 0.227 | 0.1991 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0327 | 0.227 | 0.2522 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0707 | 0.5333 | 0.8461 |
Echinococcus granulosus | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0327 | 0.227 | 0.3602 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0513 | 0.0171 |
Echinococcus multilocularis | adenylate cyclase type IX | 0.0827 | 0.6303 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1184 | 0.9176 | 0.9146 |
Loa Loa (eye worm) | hypothetical protein | 0.1034 | 0.797 | 0.7897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.1034 | 0.797 | 0.7897 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0707 | 0.5333 | 1 |
Schistosoma mansoni | adenylate cyclase | 0.0089 | 0.0348 | 0.0653 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0707 | 0.5333 | 0.8461 |
Loa Loa (eye worm) | hypothetical protein | 0.0707 | 0.5332 | 0.5164 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0707 | 0.5333 | 0.654 |
Echinococcus granulosus | GPCR family 2 | 0.0327 | 0.227 | 0.3602 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0327 | 0.227 | 0.2522 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1034 | 0.797 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.227 | 0.1991 |
Schistosoma mansoni | hypothetical protein | 0.0707 | 0.5332 | 0.9998 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0131 | 0.0689 | 0.1292 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0547 | 0.4045 | 0.6418 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0327 | 0.227 | 0.4257 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0131 | 0.0689 | 0.5 |
Onchocerca volvulus | Adenylate cyclase type 3 homolog | 0.1212 | 0.9405 | 1 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0131 | 0.0689 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.1034 | 0.797 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0327 | 0.227 | 0.3602 |
Echinococcus multilocularis | adenylate cyclase 9 | 0.0089 | 0.0348 | 0.0552 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0327 | 0.227 | 0.3602 |
Brugia malayi | Adenylyl cyclase protein | 0.0547 | 0.4045 | 0.485 |
Onchocerca volvulus | Adenylate cyclase type 2 homolog | 0.0547 | 0.4045 | 0.041 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0131 | 0.0689 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0327 | 0.227 | 0.3602 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0131 | 0.0689 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.