Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0000014017 | 0.0000014017 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0029 | 0 | 0.5 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0000014017 | 0.0000014017 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0029 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0029 | 0 | 0.5 |
Brugia malayi | olfactory channel protein osm-9 | 0.0029 | 0.0000014017 | 0.0000014017 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0029 | 0.0000014017 | 0.0000014017 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0000014017 | 0.0000014017 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0029 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 482 nM | Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis | ChEMBL. | 23643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.