Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminyl-peptide cyclotransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Onchocerca volvulus | Glutaminyl cyclase homolog | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma japonicum | ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Brugia malayi | Peptidase family M28 containing protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | Get druggable targets OG5_129821 | All targets in OG5_129821 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | glutaminyl-peptide cyclotransferase | 361 aa | 292 aa | 21.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.2622 | 0.2622 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0136 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.2622 | 0.2622 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2187 | 0.1366 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2187 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2622 | 0.2622 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2187 | 0.1366 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1152 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2187 | 0.117 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1152 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0136 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1152 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.095 | 0.095 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1152 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1152 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1152 | 0.1152 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2187 | 0.2187 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2187 | 0.2187 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2187 | 0.117 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.095 | 0.095 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2187 | 0.1366 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1152 | 0.0222 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.2622 | 0.2622 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2187 | 0.117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 185 nM | Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis | ChEMBL. | 23643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.