Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0703 | 0.5964 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0441 | 0.2829 | 0.4567 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0222 | 0.0194 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.092 | 0.1082 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0511 | 0.3668 | 0.5958 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0578 | 0.4467 | 0.7364 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0229 | 0.0284 | 0.0156 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1039 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0441 | 0.2829 | 0.2687 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0703 | 0.5964 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0296 | 0.1083 | 0.1406 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1039 | 1 | 1 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0703 | 0.5964 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0336 | 0.1572 | 0.2387 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0421 | 0.258 | 0.4135 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0703 | 0.5964 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0421 | 0.258 | 0.2433 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0679 | 0.568 | 0.9499 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0441 | 0.2829 | 0.4567 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0703 | 0.5964 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0229 | 0.0284 | 0.0092 |
Entamoeba histolytica | protein kinase, putative | 0.0441 | 0.2829 | 0.4481 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0703 | 0.5964 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0578 | 0.4467 | 0.7364 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0441 | 0.2829 | 0.3327 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0914 | 0.8503 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0441 | 0.2829 | 0.4481 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0703 | 0.5964 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0441 | 0.2829 | 0.2687 |
Trichomonas vaginalis | AGC family protein kinase | 0.0441 | 0.2829 | 0.4481 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0441 | 0.2829 | 0.2687 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.258 | 0.3035 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0511 | 0.3668 | 0.5958 |
Trichomonas vaginalis | AGC family protein kinase | 0.0441 | 0.2829 | 0.4481 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0441 | 0.2829 | 0.3327 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0421 | 0.258 | 0.2433 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0229 | 0.0284 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0229 | 0.0284 | 0.0477 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0386 | 0.2171 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 52 nM | Inhibition of MK2 (unknown origin) phosphorylation using TAMRA labeled peptide as substrate incubated 30 mins before substrate addition measured after 30 mins | ChEMBL. | 23602398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.