Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Trypanosoma cruzi | 5'-AMP-activated protein kinase subunit beta, putative | 0.0068 | 0.0084 | 0.5 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6368 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0764 | 0.1179 | 0.1179 |
Echinococcus granulosus | stromal interaction molecule 1 | 0.1409 | 0.2195 | 0.2195 |
Schistosoma mansoni | protein kinase | 0.0278 | 0.0414 | 0.0414 |
Echinococcus multilocularis | sterile alpha and tir motif containing protein | 0.0112 | 0.0153 | 0.0148 |
Brugia malayi | coiled-coil like protein 1 | 0.0112 | 0.0153 | 0.0069 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0278 | 0.0414 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0005 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.0245 | 1 |
Schistosoma mansoni | protein kinase subunit beta | 0.0037 | 0.0035 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0153 | 0.0069 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0005 | 0.0005 |
Echinococcus granulosus | Sterile alpha motif SAM | 0.0112 | 0.0153 | 0.0153 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0278 | 0.0415 | 0.0334 |
Loa Loa (eye worm) | TKL/STKR/TYPE2 protein kinase | 0.0148 | 0.0209 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus multilocularis | SAM domain containing protein | 0.0112 | 0.0153 | 0.0148 |
Brugia malayi | protein C17H12.11 | 0.0147 | 0.0208 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.1409 | 0.2195 | 0.2195 |
Echinococcus multilocularis | serine:threonine protein kinase receptor R3 | 0.0173 | 0.0249 | 0.0244 |
Echinococcus granulosus | activin receptor type | 0.0528 | 0.0808 | 0.0808 |
Loa Loa (eye worm) | toll and interleukin 1 receptor domain-containing protein isoform f | 0.0112 | 0.0153 | 0.0153 |
Plasmodium vivax | tyrosine kinase-like protein, putative | 0.0113 | 0.0155 | 0.5 |
Echinococcus multilocularis | liprin beta 1 | 0.0112 | 0.0153 | 0.0148 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Schistosoma mansoni | lip-related protein (liprin) alpha | 0.0112 | 0.0153 | 0.0153 |
Trichomonas vaginalis | c2h2 zinc finger protein, putative | 0.0112 | 0.0153 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0645 | 0.0993 | 0.0992 |
Echinococcus granulosus | 5' AMP activated protein kinase subunit beta 1 | 0.0037 | 0.0035 | 0.0035 |
Plasmodium falciparum | tyrosine kinase-like protein | 0.0113 | 0.0155 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0148 | 0.0209 | 0.0209 |
Echinococcus multilocularis | 5' AMP activated protein kinase subunit beta 1 | 0.0037 | 0.0035 | 0.003 |
Echinococcus multilocularis | activin receptor type | 0.0528 | 0.0808 | 0.0804 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.0264 | 0.0264 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Echinococcus multilocularis | liprin alpha 2 | 0.0112 | 0.0153 | 0.0148 |
Brugia malayi | sterile alpha and TIR motif containing protein 1 isoform a | 0.0112 | 0.0153 | 0.0069 |
Brugia malayi | Protein kinase domain containing protein | 0.0148 | 0.0209 | 0.0126 |
Onchocerca volvulus | 0.0167 | 0.0239 | 0.9649 | |
Echinococcus granulosus | liprin alpha 2 | 0.0112 | 0.0153 | 0.0153 |
Onchocerca volvulus | 0.0112 | 0.0153 | 0.4703 | |
Trypanosoma brucei | 5'-AMP-activated protein kinase subunit beta | 0.0068 | 0.0084 | 0.5 |
Echinococcus multilocularis | tankyrase | 0.0112 | 0.0153 | 0.0148 |
Loa Loa (eye worm) | 5'-AMP-activated protein kinase | 0.0068 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.6368 | 1 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0278 | 0.0415 | 0.0415 |
Echinococcus granulosus | tankyrase | 0.0112 | 0.0153 | 0.0153 |
Echinococcus multilocularis | AMPK beta subunit | 0.0068 | 0.0084 | 0.008 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0278 | 0.0414 | 0.0414 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Schistosoma mansoni | tankyrase | 0.0112 | 0.0153 | 0.0153 |
Toxoplasma gondii | Tyrosine kinase-like (TKL) protein | 0.0112 | 0.0154 | 1 |
Echinococcus granulosus | sterile alpha and tir motif containing protein | 0.0112 | 0.0153 | 0.0153 |
Trypanosoma cruzi | SNF1-related protein kinase regulatory subunit beta, putative | 0.0068 | 0.0084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Giardia lamblia | 5-AMP-activated protein kinase, beta-1 subunit | 0.0068 | 0.0084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0208 | 0.0208 |
Schistosoma mansoni | protein kinase subunit beta | 0.0068 | 0.0084 | 0.0084 |
Schistosoma mansoni | lar interacting protein (lip)-related protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | liprin beta 1 | 0.0112 | 0.0153 | 0.0153 |
Brugia malayi | Liprin-alpha 2 | 0.0112 | 0.0153 | 0.0069 |
Brugia malayi | Tnks protein | 0.0112 | 0.0153 | 0.0069 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0112 | 0.0153 | 0.5 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0278 | 0.0414 | 0.0414 |
Echinococcus granulosus | AMPK beta subunit | 0.0068 | 0.0084 | 0.0084 |
Schistosoma mansoni | Protein orai-1 | 0.6368 | 1 | 1 |
Schistosoma mansoni | sarm1 | 0.0112 | 0.0153 | 0.0153 |
Plasmodium falciparum | protein kinase, putative | 0.0113 | 0.0155 | 0.5 |
Brugia malayi | Neurabin protein 1 | 0.0112 | 0.0153 | 0.0069 |
Echinococcus multilocularis | stromal interaction molecule 1 | 0.1409 | 0.2195 | 0.2191 |
Schistosoma mansoni | protein kinase | 0.0173 | 0.025 | 0.025 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.0084 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.0264 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0005 |
Brugia malayi | hypothetical protein | 0.0147 | 0.0208 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0153 | 0.0153 |
Echinococcus granulosus | SAM domain containing protein | 0.0112 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.1409 | 0.2195 | 0.2129 |
Onchocerca volvulus | 0.0112 | 0.0153 | 0.4703 | |
Schistosoma mansoni | Protein orai-1 | 0.6368 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.