Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0376 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0033 | 0.0215 | 0.0215 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0376 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0033 | 0.0215 | 0.0215 |
Onchocerca volvulus | 0.0033 | 0.0215 | 1 | |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0033 | 0.0215 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0376 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0033 | 0.0215 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0376 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0033 | 0.0215 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0033 | 0.0215 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0033 | 0.0215 | 0.0215 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0033 | 0.0215 | 0.0215 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0033 | 0.0215 | 0.0215 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0033 | 0.0215 | 0.0215 |
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0376 | 1 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0376 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0376 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0376 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.