Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2461 | 0.8699 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2461 | 0.8699 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2461 | 0.8699 | 0.7866 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1189 | 0.3905 | 0.4489 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1593 | 0.5427 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.2807 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2461 | 0.8699 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2461 | 0.8699 | 0.7866 |
Leishmania major | carbonic anhydrase family protein, putative | 0.2807 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1189 | 0.3905 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.2807 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1189 | 0.3905 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.1189 | 0.3905 | 0.4489 |
Schistosoma mansoni | carbonic anhydrase | 0.2807 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Echinococcus multilocularis | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0634 | 0.1813 | 0.2084 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2461 | 0.8699 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 0.1813 | 0.2084 |
Echinococcus multilocularis | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Echinococcus granulosus | carbonic anhydrase II | 0.2461 | 0.8699 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1189 | 0.3905 | 0.4489 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2461 | 0.8699 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1214 | 0.3998 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1189 | 0.3905 | 0.4489 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1189 | 0.3905 | 0.4489 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2461 | 0.8699 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1189 | 0.3905 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Loa Loa (eye worm) | hypothetical protein | 0.1189 | 0.3905 | 0.4489 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2461 | 0.8699 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1189 | 0.3905 | 0.4489 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1214 | 0.3998 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2461 | 0.8699 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1189 | 0.3905 | 0.4489 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 135 nM | Partial agonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 3 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Emax (functional) | = 18 % | Partial agonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding after 3 hrs by liquid scintillation counting analysis relative to (-)-U50,488 | ChEMBL. | 23618710 |
Ke (functional) | = 8 nM | Antagonist activity at human recombinant mu opioid receptor expressed in CHO cell membranes assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ke (functional) | = 32 nM | Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cell membranes assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ke (functional) | = 64 nM | Antagonist activity at human recombinant delta opioid receptor expressed in mouse/rat NG108-15 cell membranes assessed as inhibition of SNC80-induced [35S]GTPgammaS binding by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ki (binding) | = 5 nM | Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ki (binding) | = 16 nM | Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Ki (binding) | = 24 nM | Displacement of [3H]DADLE from human recombinant delta opioid receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 23618710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.