Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.0197 | 0.0215 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.1197 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Onchocerca volvulus | 0.0264 | 0.0875 | 1 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) | 0.0264 | 0.0875 | 0.0675 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0264 | 0.0875 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Mycobacterium ulcerans | phosphoribosylaminoimidazole synthetase | 0.0264 | 0.0875 | 0.0675 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.1197 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0197 | 0.0215 | 0.2455 |
Schistosoma mansoni | dihydrofolate reductase | 0.0197 | 0.0215 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.