Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Mycobacterium ulcerans | thymidylate synthase | 0.0188 | 0.6707 | 0.9096 |
Echinococcus granulosus | thymidylate synthase | 0.0188 | 0.6707 | 0.9237 |
Echinococcus multilocularis | thymidylate synthase | 0.0188 | 0.6707 | 0.9237 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0188 | 0.6707 | 0.9221 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Chlamydia trachomatis | dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0062 | 0.1306 | 0.1383 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0089 | 0.2473 | 0.1965 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0062 | 0.1306 | 0.1383 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0265 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.02 | 0.7244 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0265 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0188 | 0.6707 | 0.9259 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0089 | 0.2473 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0089 | 0.2473 | 0.1342 |
Brugia malayi | Dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Onchocerca volvulus | 0.0188 | 0.6707 | 1 | |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.02 | 0.7244 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0265 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0265 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0062 | 0.1306 | 0.1383 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0208 | 0.0288 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0188 | 0.6707 | 0.9096 |
Schistosoma mansoni | dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0062 | 0.1306 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0062 | 0.1306 | 0.1561 |
Echinococcus multilocularis | 0.0062 | 0.1306 | 0.1561 | |
Echinococcus granulosus | dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0062 | 0.1306 | 0.1561 |
Brugia malayi | hypothetical protein | 0.0089 | 0.2473 | 0.3219 |
Echinococcus multilocularis | dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0062 | 0.1306 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1803 |
Brugia malayi | hypothetical protein | 0.0062 | 0.1306 | 0.1561 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0265 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.02 | 0.7244 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0062 | 0.1306 | 0.1561 |
Schistosoma mansoni | amine oxidase | 0.0062 | 0.1306 | 0.1383 |
Brugia malayi | thymidylate synthase | 0.0188 | 0.6707 | 0.9237 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.02 | 0.7244 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0188 | 0.6707 | 0.9096 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0062 | 0.1306 | 0.1561 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.02 | 0.7244 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.