Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydropteridine reductase | 0.0025 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0369 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0369 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0369 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0369 | 1 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0036 | 0.0332 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0036 | 0.0332 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0036 | 0.0332 | 0.0332 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0036 | 0.0332 | 0.0332 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0036 | 0.0332 | 0.0332 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0036 | 0.0332 | 0.0332 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0036 | 0.0332 | 1 |
Onchocerca volvulus | 0.0036 | 0.0332 | 1 | |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0036 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0025 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0369 | 1 | 1 |
Leishmania major | pteridine reductase 1 | 0.0036 | 0.0332 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0025 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0036 | 0.0332 | 0.0332 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0369 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.7 uM | Antagonist activity at P2Y12 receptor (unknown origin) assessed as inhibition of GTPgammaS binding after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
IC50 (binding) | = 2.4 uM | Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.