Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-gated potassium channel | 0.011 | 0.5702 | 0.9166 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.1886 | 0.1886 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.005 | 0.0278 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0447 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.622 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.4749 | 0.4749 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.622 | 1 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1886 | 0.3032 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.622 | 0.622 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.4749 | 0.7634 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.005 | 0.0278 | 0.0278 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0157 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.4749 | 0.7634 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.4749 | 0.4749 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.005 | 0.0278 | 0.0278 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1886 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.