Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin B3 1 | 0.006 | 0.0405 | 0.1075 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0405 | 0.0405 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0136 | 0.3764 | 1 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.006 | 0.0405 | 0.0405 |
Echinococcus granulosus | cyclins | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Schistosoma mansoni | cyclin B3 | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin D, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclin b3 | 0.006 | 0.0405 | 0.1075 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.006 | 0.0405 | 0.1075 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0136 | 0.3764 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Giardia lamblia | Cyclin A | 0.006 | 0.0405 | 0.1075 |
Trypanosoma brucei | mitotic cyclin 6 | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.006 | 0.0405 | 0.0405 |
Leishmania major | cyclin | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0279 | 1 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.006 | 0.0405 | 0.1075 |
Toxoplasma gondii | AGC kinase | 0.0136 | 0.3764 | 1 |
Toxoplasma gondii | AGC kinase | 0.0136 | 0.3764 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Echinococcus granulosus | cyclins | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0136 | 0.3764 | 1 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Echinococcus granulosus | cyclins | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclins, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0136 | 0.3764 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0136 | 0.3764 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0136 | 0.3764 | 1 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0136 | 0.3764 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0136 | 0.3764 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | cyclin B | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0136 | 0.3764 | 0.3764 |
Entamoeba histolytica | cyclin family protein | 0.006 | 0.0405 | 0.1075 |
Leishmania major | protein kinase A catalytic subunit | 0.0136 | 0.3764 | 1 |
Onchocerca volvulus | 0.006 | 0.0405 | 0.5 | |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | AGC family protein kinase | 0.0136 | 0.3764 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin B, putative | 0.006 | 0.0405 | 0.1075 |
Giardia lamblia | Hypothetical protein | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclin B | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin D, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0405 | 0.0405 |
Schistosoma mansoni | cyclins | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin B, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0134 | 0.3651 | 0.97 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0136 | 0.3764 | 1 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0134 | 0.3651 | 0.97 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0136 | 0.3764 | 0.3764 |
Entamoeba histolytica | cyclin, putative | 0.006 | 0.0405 | 0.1075 |
Schistosoma mansoni | cyclin B | 0.006 | 0.0405 | 0.1075 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0136 | 0.3764 | 1 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0136 | 0.3764 | 0.3764 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.006 | 0.0405 | 0.0405 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0136 | 0.3764 | 1 |
Echinococcus granulosus | cyclins | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Entamoeba histolytica | cyclin family protein | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclins, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0136 | 0.3764 | 1 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0136 | 0.3764 | 1 |
Plasmodium falciparum | cyclin | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0136 | 0.3764 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus multilocularis | cyclins | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin A, putative | 0.006 | 0.0405 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.3764 | 0.3764 |
Entamoeba histolytica | cyclin, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | cyclins | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cyclin, putative | 0.006 | 0.0405 | 0.1075 |
Echinococcus granulosus | cyclin b3 | 0.006 | 0.0405 | 0.1075 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.006 | 0.0405 | 0.0405 |
Trypanosoma cruzi | cyclin, putative | 0.006 | 0.0405 | 0.1075 |
Trichomonas vaginalis | cyclin B, putative | 0.006 | 0.0405 | 0.1075 |
Trypanosoma cruzi | cyclin 6, putative | 0.006 | 0.0405 | 0.1075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 110 uM | Cytotoxicity against human HeLa cells after 48 hrs by MTT assay | ChEMBL. | 23748152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.