Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0513 | 0.4387 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0513 | 0.4387 | 0.3152 |
Schistosoma mansoni | dihydrofolate reductase | 0.0513 | 0.4387 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0341 | 0.1803 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0513 | 0.4387 | 0.3152 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.4871 | 0.5943 |
Loa Loa (eye worm) | hypothetical protein | 0.0767 | 0.8197 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0887 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0513 | 0.4387 | 0.5352 |
Onchocerca volvulus | 0.0887 | 1 | 1 | |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0341 | 0.1803 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0341 | 0.1803 | 0.1803 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0341 | 0.1803 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0341 | 0.1803 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0341 | 0.1803 | 0.1803 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0341 | 0.1803 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.0887 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0341 | 0.1803 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0665 | 0.6674 | 0.8143 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0341 | 0.1803 | 0.1803 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0513 | 0.4387 | 0.4387 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0341 | 0.1803 | 0.1803 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0513 | 0.4387 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0341 | 0.1803 | 0.411 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0341 | 0.1803 | 0.1803 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0341 | 0.1803 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0341 | 0.1803 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0513 | 0.4387 | 0.3152 |
Loa Loa (eye worm) | aminopeptidase N | 0.0341 | 0.1803 | 0.22 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0341 | 0.1803 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0513 | 0.4387 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0341 | 0.1803 | 0.1803 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0341 | 0.1803 | 0.411 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0341 | 0.1803 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0341 | 0.1803 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0513 | 0.4387 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 1.67 uM | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability after 24 hrs by MTS assay | ChEMBL. | 23232148 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 23232148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.