TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 289.396 | Formula: C15H19N3OS
H donors: 1 H acceptors: 1 LogP: 4.04 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=NNc1scc(n1)c1ccc(cc1)OC)CC
InChi: 1S/C15H19N3OS/c1-4-12(5-2)17-18-15-16-14(10-20-15)11-6-8-13(19-3)9-7-11/h6-10H,4-5H2,1-3H3,(H,16,18)
InChiKey: QJPUURMHMCBJFX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0055	0.0851	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0158	0.0496
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.0409	0.1284
Brugia malayi	GnHR receptor homolog	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Plasmodium falciparum	protein kinase 7	0.032	0.6542	0.6542
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0409	0.1284
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.0409	0.0751
Echinococcus granulosus	orexin receptor type 2	0.0035	0.0409	0.1284
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0409	0.0751
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.051	0.5986
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0413	0.5342
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.0409	0.0751
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0201	0.037
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0388	0.9253
Brugia malayi	sulfakinin receptor protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0035	0.0409	0.0751
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.0409	0.1284
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0388	0.122
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.0409	0.0751
Schistosoma mansoni	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0409	0.0751
Mycobacterium ulcerans	glutaminase	0.0269	0.5445	1
Leishmania major	protein kinase, putative	0.0035	0.0404	0.474
Schistosoma mansoni	glucose transport protein	0.0113	0.2094	0.3846
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.051	0.6589
Onchocerca volvulus		0.0035	0.0409	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.0409	0.0751
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.2094	0.3846
Brugia malayi	RE15519p	0.0035	0.0409	0.0751
Echinococcus multilocularis	serotonin receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0409	0.1284
Onchocerca volvulus		0.0035	0.0409	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0183	0.3595	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0201	0.0632
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.0409	0.1284
Echinococcus granulosus	General substrate transporter	0.0097	0.1752	0.5501
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0616	0.1131
Echinococcus granulosus	somatostatin receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0851	0.2674
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0404	0.0404
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.0409	0.1284
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0201	0.037
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0413	0.5342
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	hypothetical protein	0.0113	0.2094	0.3846
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0404	0.0741
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0404	0.0404
Onchocerca volvulus		0.0035	0.0409	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0409	0.0751
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.051	0.5986
Schistosoma mansoni	glutaminase	0.0269	0.5445	1
Schistosoma mansoni	histamine h1 receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	hypothetical protein	0.0035	0.0409	0.1284
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0773	0.0773
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0055	0.0851	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0409	0.1284
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0404	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0409	0.1284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0413	0.5342
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.0409	0.0751
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.007	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0119	0.1401
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0409	0.1284
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0388	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Trichomonas vaginalis	glutaminase, putative	0.0269	0.5445	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0695	0.1276
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0388	0.0713
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.0409	0.1284
Leishmania major	glucose transporter, lmgt1	0.0035	0.0413	0.4853
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0404	0.1267
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	larval opioid receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0404	0.0617
Schistosoma mansoni	hypothetical protein	0.0164	0.3184	0.5848
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0409	0.1284
Brugia malayi	neuropeptide F receptor	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.048	1	1
Schistosoma mansoni	glucose transport protein	0.0113	0.2094	0.3846
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0388	0.0713
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0201	0.3046
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0183	0.3595	0.3595
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0404	0.0404
Leishmania major	glucose transporter, lmgt2	0.0035	0.0413	0.4853
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0695	0.1276
Plasmodium falciparum	hexose transporter	0.0113	0.2094	0.2094
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	Serotonin receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	serotonin receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0183	0.3595	0.3595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.0409	0.1284
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.0409	0.1284
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0404	0.0741
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Leishmania major	glucose transporter, lmgt3	0.0035	0.0413	0.4853
Schistosoma mansoni	protein kinase	0.0035	0.0404	0.0741
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0695	0.1276
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0773	1
Onchocerca volvulus		0.0035	0.0409	1
Leishmania major	hypothetical protein, conserved	0.0052	0.0773	0.9084
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0409	0.1284
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0388	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0404	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.0409	0.1284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0409	0.1284
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0413	0.0759
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	allatostatin A receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0201	0.037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0616	0.1935
Schistosoma mansoni	hypothetical protein	0.0023	0.0158	0.029
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0201	0.5
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0413	0.0759
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0388	1
Onchocerca volvulus		0.0035	0.0409	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0413	0.5342
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	fmrfamide receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.0409	0.1284
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0113	0.2094	0.6577
Trypanosoma cruzi	hexose transporter	0.0035	0.0413	0.5342
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0404	0.0404
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Onchocerca volvulus		0.0035	0.0409	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Entamoeba histolytica	protein kinase, putative	0.0035	0.0404	1
Brugia malayi	Sugar transporter family protein	0.0113	0.2094	0.3846
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0201	0.037
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0134	0.0247
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0201	0.2603
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.0409	0.1284
Schistosoma mansoni	hypothetical protein	0.0033	0.0367	0.0673
Plasmodium falciparum	proline--tRNA ligase	0.004	0.051	0.051
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0413	0.4853
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0409	0.1284
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0404	0.0617
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.051	0.6589
Echinococcus granulosus	geminin	0.0164	0.3184	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0616	0.1935
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.0409	0.1284
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0201	0.0308
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0409	0.1284
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0201	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0616	0.1131
Schistosoma mansoni	adenoreceptor	0.0035	0.0409	0.0751
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0388	0.0713
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0409	0.0751
Brugia malayi	AKH receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0201	0.037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	hypothetical protein	0.0164	0.3184	0.5848
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	somatostatin receptor	0.0035	0.0409	0.1284
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.051	0.051
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.0409	0.0751
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0409	0.0751
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0409	0.0751
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0119	0.1401
Onchocerca volvulus		0.0035	0.0409	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0409	0.1284
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0409	0.0751
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0413	0.0759
Loa Loa (eye worm)	sugar transporter	0.0113	0.2094	0.3846
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.0409	0.1284
Brugia malayi	G protein-coupled receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0388	0.122
Echinococcus multilocularis	geminin	0.0164	0.3184	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0616	0.1935
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0413	0.5342
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0201	0.037
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0773	1
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.0409	0.1284
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.0773	1
Toxoplasma gondii	protein kinase, putative	0.032	0.6542	1
Loa Loa (eye worm)	glutaminase 2	0.0269	0.5445	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.0773	0.0773
Schistosoma mansoni	myosin xvIII	0.0035	0.0409	0.0751
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0409	0.1284
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.0409	0.0751
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0851	0.1564
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0851	0.1564
Brugia malayi	neuropeptide F receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0616	0.1131
Toxoplasma gondii	facilitative glucose transporter GT1	0.0113	0.2094	0.3201
Brugia malayi	glutaminase DH11.1	0.0269	0.5445	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0616	0.1131
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0413	0.0759
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.0409	0.0751
Schistosoma mansoni	opsin-like receptor	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0388	0.0713
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0409	0.1284
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.051	0.6589
Echinococcus granulosus	allatostatin A receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0251	0.0462
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.0409	0.1284
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0409	0.0751
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0409	0.1284
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0404	0.0617
Onchocerca volvulus		0.0035	0.0409	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.0409	0.0751
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0413	0.0759
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0404	0.0404
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0201	0.0201
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0409	0.0751
Schistosoma mansoni	protein kinase	0.0035	0.0404	0.0741
Schistosoma mansoni	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	amine GPCR	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Brugia malayi	Dopamine receptor protein 2	0.0035	0.0409	0.0751
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0404	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	glucose transport protein	0.0113	0.2094	0.3846
Schistosoma mansoni	amine GPCR	0.0035	0.0409	0.0751
Plasmodium vivax	hexose transporter	0.0113	0.2094	0.2094
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0771	0.1416
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.0409	0.1284
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0413	0.0759
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0409	0.1284
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Loa Loa (eye worm)	glutaminase	0.0269	0.5445	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0773	0.0773
Schistosoma mansoni	hypothetical protein	0.0035	0.0409	0.0751
Onchocerca volvulus		0.0035	0.0409	1
Brugia malayi	Dopamine receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0357	0.1122
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0409	0.0751
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0035	0.0409	1
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Schistosoma mansoni	amine GPCR	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0773	0.142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0695	0.1276
Onchocerca volvulus		0.0035	0.0409	1
Brugia malayi	Serotonin receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0409	0.1284
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.0409	0.0751
Brugia malayi	G-protein coupled receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0357	0.1122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0409	0.0751
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0055	0.0851	0.2674
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0413	0.0759
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.0773	0.1182
Onchocerca volvulus		0.0035	0.0409	1
Brugia malayi	hypothetical protein	0.0052	0.0773	0.142
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.0409	0.1284
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0413	0.5342
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0404	0.0741
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.051	0.0779
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0409	0.0751
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0616	0.1131
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0055	0.0851	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0409	0.1284
Brugia malayi	Dopamine receptor protein 1	0.0035	0.0409	0.0751
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0409	0.0751
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0404	0.0404
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.0409	0.0751
Echinococcus multilocularis	General substrate transporter	0.0097	0.1752	0.5501
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	protein kinase	0.0035	0.0404	0.0741
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.0409	0.0751
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.0409	0.0751
Schistosoma mansoni	amine GPCR	0.0035	0.0409	0.0751
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0404	0.5218
Schistosoma mansoni	opsin-like receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.0409	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0158	0.0496
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.0409	0.0751
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0201	0.2364
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	putative neuropeptide receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	sex peptide receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0409	0.1284
Schistosoma mansoni	amine GPCR	0.0035	0.0409	0.0751
Brugia malayi	hypothetical protein	0.0033	0.0378	0.0694
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0616	0.1935
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0055	0.0851	1
Onchocerca volvulus		0.0035	0.0409	1
Brugia malayi	Melatonin receptor type 1A	0.0035	0.0409	0.0751
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0113	0.2094	0.6577
Brugia malayi	Cam kinase protein 1	0.0035	0.0404	0.0741
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0409	0.1284
Brugia malayi	G-protein coupled receptor	0.0035	0.0409	0.0751
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0388	1
Brugia malayi	ORL1-like opioid receptor	0.0035	0.0409	0.0751
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0409	0.1284
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0409	0.1284
Echinococcus multilocularis	serotonin receptor	0.0035	0.0409	0.1284
Echinococcus multilocularis	sex peptide receptor	0.0035	0.0409	0.1284
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0409	0.0751
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0035	0.0409	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0201	0.5182
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0367	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.0409	0.1284
Schistosoma mansoni	opsin-like receptor	0.0035	0.0409	0.0751
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0404	0.0404
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.0409	0.0751
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0404	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0367	0.0673
Brugia malayi	hypothetical protein	0.0035	0.0409	0.0751
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0201	0.2603
Entamoeba histolytica	protein kinase, putative	0.0035	0.0404	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.0409	0.0751
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0409	0.0751
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0409	0.1284
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0404	0.0741
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0201	0.037
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0388	0.0713
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0404	0.1267
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0409	0.0751
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0201	0.0632
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0409	0.1284

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 16 ug ml-1	Anticandida activity against Candida albicans clinical isolate assessed as growth inhibition after 24 hrs by broth microdilution method	ChEMBL.	23702472
MIC (functional)	> 256 ug ml-1	Antibacterial activity against Escherichia coli assessed as growth inhibition after 18 to 22 hrs by broth microdilution method	ChEMBL.	23702472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2402810

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1781920