Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 6-phosphofructokinase | 0.0105 | 0.5965 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0105 | 0.5965 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.9023 | 0.7579 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0105 | 0.5965 | 0.5 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0105 | 0.5965 | 0.5 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0028 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0105 | 0.5965 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.9023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.9023 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.9023 | 0.7579 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0157 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.9023 | 1 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0105 | 0.5965 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.9023 | 0.7579 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0028 | 0 | 0.5 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0028 | 0 | 0.5 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0105 | 0.5965 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0105 | 0.5965 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0105 | 0.5965 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0105 | 0.5965 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 29.64 uM | Cytotoxicity against human HepG2 cells assessed as cell survival after 48 hrs by SRB assay | ChEMBL. | 23708013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.